TLR7

Description		toll like receptor 7
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Endosome Membrane Integral Component Of Membrane Early Phagosome Endolysosome Membrane Receptor Complex
	Molecular Function	Double-stranded RNA Binding Single-stranded RNA Binding Transmembrane Signaling Receptor Activity Drug Binding SiRNA Binding Pattern Recognition Receptor Activity
	Biological Process	Microglial Cell Activation Regulation Of Protein Phosphorylation Toll-like Receptor Signaling Pathway Inflammatory Response Immune Response I-kappaB Kinase/NF-kappaB Signaling I-kappaB Phosphorylation Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Toll-like Receptor 7 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Innate Immune Response Positive Regulation Of Inflammatory Response Defense Response To Virus Cellular Response To Mechanical Stimulus Positive Regulation Of NIK/NF-kappaB Signaling
Pathways		Trafficking and processing of endosomal TLR Toll Like Receptor 7/8 (TLR7/8) Cascade Potential therapeutics for SARS TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation MyD88 dependent cascade initiated on endosome
Drugs		Imiquimod Hydroxychloroquine Isatoribine ANA971 Golotimod Resiquimod
Diseases
GWAS		Celiac disease ( 20190752)
Interacting Genes		2 interacting genes: GRAMD1A MYD88
Entrez ID		51284
HPRD ID		02295
Ensembl ID		ENSG00000196664
Uniprot IDs		B2R9N9 Q9NYK1
PDB IDs
Enriched GO Terms of Interacting Partners?
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