PLEKHO1 and SMG5

Data Source:
BioGRID (affinity chromatography technology)

		PLEKHO1	SMG5
Description		pleckstrin homology domain containing O1	SMG5 nonsense mediated mRNA decay factor
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GO Annotations	Cellular Component	Nucleus Cytoplasm Ruffle Membrane Muscle Cell Projection Membrane	Nucleus Telomerase Holoenzyme Complex Cytoplasm Cytosol
	Molecular Function	Protein Binding	Protein Binding Ubiquitin Protein Ligase Binding Telomeric DNA Binding Histone Deacetylase Binding Protein Phosphatase 2A Binding Telomerase RNA Binding
	Biological Process	Myoblast Fusion Regulation Of Cell Shape Myoblast Migration Lamellipodium Morphogenesis	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Export From Nucleus Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Dephosphorylation
Pathways			Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656)	Glycated hemoglobin levels ( 29170429) Hemoglobin A1c levels ( 29403010) Mean corpuscular hemoglobin concentration ( 29403010 20139978)
Interacting Genes		32 interacting genes: ADAM33 AKT1 AKT2 BNIP2 BRICD5 C10orf88 C4orf3 CEP19 COL8A2 CSNK2A1 CYP4F2 DNAJB1 FLNB IFI35 LRP10 MMD NAPB PSMC5 RPS20 SMAD5 SMURF1 THSD7B TMEM218 TNF TRAF3IP3 TRAF6 TRAM1L1 TSPAN33 TSPO2 USP7 VAMP3 ZFPL1	7 interacting genes: APP SMG1 SMG6 SMG7 STUB1 TERT UPF1
Entrez ID		51177	23381
HPRD ID		12217	16869
Ensembl ID		ENSG00000023902	ENSG00000198952
Uniprot IDs		Q53GL0 Q5T4P9	Q9UPR3
PDB IDs		3AA1	2HWY
Enriched GO Terms of Interacting Partners?
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