INSIG2 and CYBC1

Data Source:
BioGRID (two hybrid)

		INSIG2	CYBC1
Description		insulin induced gene 2	cytochrome b-245 chaperone 1
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane SREBP-SCAP-Insig Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Oxysterol Binding	Protein Binding
	Biological Process	Cholesterol Biosynthetic Process Sterol Biosynthetic Process Cellular Response To Insulin Stimulus SREBP Signaling Pathway SREBP-SCAP Complex Retention In Endoplasmic Reticulum	Innate Immune Response Respiratory Burst After Phagocytosis
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF)
Drugs
Diseases
GWAS		Apolipoprotein B levels ( 32203549) Cholesterol, total ( 24097068) Depression in response to interferon-based therapy in chronic hepatitis C ( 27723809) Heel bone mineral density ( 30598549 28869591) LDL cholesterol ( 24097068 30275531) LDL cholesterol levels ( 32203549 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Low density lipoprotein cholesterol levels ( 32154731) Lumbar spine bone mineral density ( 22504420) Monobrow ( 27182965) Mosquito bite size ( 28199695) Total cholesterol levels ( 30275531)
Interacting Genes		46 interacting genes: ABHD4 AQP2 AQP6 ATP6V0B BIK CD40 CD79A CPLX4 CREB3L1 CYBC1 EBP FAM209A GJA8 GOLM1 GPR152 GPR37L1 GPX8 HSD17B13 IFNGR2 KIR2DL3 LAPTM5 LHFPL5 LMNA MMGT1 MUC1 NEMP1 PRLR PSCA PSMA7 PSMB1 PSMC3 PSMC5 PVR RNF5 SCAP SCN3B SLC16A10 SREBF2 STIM1 TMEM14B TMEM237 TMEM45B TMEM52B TMX2 VCP VMA21	64 interacting genes: ADIPOQ AGTRAP AHNAK2 AIG1 APCDD1L APOA2 APOL2 AQP10 AQP6 AQP8 BET1 C14orf180 C4orf3 CD53 CISD2 CLDN7 CLN6 COQ9 CPLX4 CREB3 CREB3L1 CYBB ERGIC3 ETS1 FAM209A GJA8 GPR151 GPR152 HSD17B11 HSD17B13 INSIG2 JAGN1 KASH5 KIR2DL3 LAT LMNA LXN MFF MFSD14B MGST3 MTIF3 NINJ2 NOX3 NRM P2RX1 PDZK1IP1 PEX12 PLIN3 PLP1 PLP2 SCD SHISA4 SLC35C2 SPN SSMEM1 STX2 THBD TM4SF19 TMEM128 TMEM80 TMPRSS2 TMX2 TRAM1L1 TSPAN12
Entrez ID		51141	79415
HPRD ID		16361	14630
Ensembl ID		ENSG00000125629	ENSG00000178927
Uniprot IDs		A0A024RAI2 B4DQ23 Q9Y5U4	A0A024R8W9 Q9BQA9
PDB IDs		4J82
Enriched GO Terms of Interacting Partners?
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