SERPINA5 and ACR

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		SERPINA5	ACR
Description		serpin family A member 5	acrosin
Image			No pdb structure
GO Annotations	Cellular Component	Acrosomal Membrane Extracellular Region Extracellular Space External Side Of Plasma Membrane Membrane Platelet Alpha Granule Platelet Dense Tubular Network Protein-containing Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-PLAT Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Collagen-containing Extracellular Matrix Extracellular Exosome Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-coagulation Factor XI Complex	Extracellular Region Nucleus Golgi-associated Vesicle Protein-containing Complex Acrosomal Matrix
	Molecular Function	Retinoic Acid Binding Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Glycosaminoglycan Binding Heparin Binding Phosphatidylcholine Binding Acrosin Binding	Protease Binding DNA Binding Amidase Activity Serine-type Endopeptidase Activity Copper Ion Binding Protein Binding Mannose Binding Serine-type Peptidase Activity Zinc Ion Binding Fucose Binding
	Biological Process	Lipid Transport Spermatogenesis Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Blood Coagulation Negative Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Seminal Vesicle Development	Acrosome Matrix Dispersal Activation Of Adenylate Cyclase Activity Single Fertilization Binding Of Sperm To Zona Pellucida Acrosome Reaction Penetration Of Zona Pellucida Response To Steroid Hormone
Pathways		Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation	Acrosome Reaction and Sperm:Oocyte Membrane Binding
Drugs		Urokinase Drotrecogin alfa Tifuvirtide PPL-100
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Serum albumin level ( 29403010) Serum total protein level ( 29403010)
Interacting Genes		22 interacting genes: ACR CBL COPS6 EPS8 F10 F11 F2 FGA FGB FGG KLK1 KLK2 KLK3 KLKB1 PIAS4 PLAT PLAU PROC RCHY1 RIDA SEMG2 THBD	3 interacting genes: SERPINA5 ZP2 ZP3
Entrez ID		5104	49
HPRD ID		03503	06342
Ensembl ID		ENSG00000188488	ENSG00000100312
Uniprot IDs		A0A024R6N9 B4DDH1 P05154	P10323
PDB IDs		1LQ8 1PAI 2HI9 2OL2 2PAI 3DY0
Enriched GO Terms of Interacting Partners?
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