SERPINA5 and KLK1

Data Source:
HPRD (in vitro)

		SERPINA5	KLK1
Description		serpin family A member 5	kallikrein 1
Image
GO Annotations	Cellular Component	Acrosomal Membrane Extracellular Region Extracellular Space External Side Of Plasma Membrane Membrane Platelet Alpha Granule Platelet Dense Tubular Network Protein-containing Complex Protein C Inhibitor-TMPRSS7 Complex Protein C Inhibitor-TMPRSS11E Complex Protein C Inhibitor-PLAT Complex Protein C Inhibitor-PLAU Complex Protein C Inhibitor-thrombin Complex Protein C Inhibitor-KLK3 Complex Protein C Inhibitor-plasma Kallikrein Complex Collagen-containing Extracellular Matrix Extracellular Exosome Protein C Inhibitor-coagulation Factor V Complex Protein C Inhibitor-coagulation Factor Xa Complex Protein C Inhibitor-coagulation Factor XI Complex	Nucleus Secretory Granule Extracellular Exosome
	Molecular Function	Retinoic Acid Binding Protease Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding Glycosaminoglycan Binding Heparin Binding Phosphatidylcholine Binding Acrosin Binding	Serine-type Endopeptidase Activity
	Biological Process	Lipid Transport Spermatogenesis Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Blood Coagulation Negative Regulation Of Endopeptidase Activity Negative Regulation Of Hydrolase Activity Seminal Vesicle Development	Regulation Of Systemic Arterial Blood Pressure Zymogen Activation
Pathways		Intrinsic Pathway of Fibrin Clot Formation Common Pathway of Fibrin Clot Formation	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Drugs		Urokinase Drotrecogin alfa Tifuvirtide PPL-100	Aluminium Benzamidine Lanoteplase Aprotinin Aniline Nafamostat Aluminium phosphate Aluminum acetate
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269) Serum albumin level ( 29403010) Serum total protein level ( 29403010)	Dental caries (decayed, missing and filled tooth surfaces) ( 31533690)
Interacting Genes		22 interacting genes: ACR CBL COPS6 EPS8 F10 F11 F2 FGA FGB FGG KLK1 KLK2 KLK3 KLKB1 PIAS4 PLAT PLAU PROC RCHY1 RIDA SEMG2 THBD	8 interacting genes: A2M ITIH4 KNG1 PROC SERPINA1 SERPINA4 SERPINA5 SERPINC1
Entrez ID		5104	3816
HPRD ID		03503	01003
Ensembl ID		ENSG00000188488	ENSG00000167748
Uniprot IDs		A0A024R6N9 B4DDH1 P05154	A0A1L2BPJ2 A0A1R3UCD2 P06870
PDB IDs		1LQ8 1PAI 2HI9 2OL2 2PAI 3DY0	1SPJ
Enriched GO Terms of Interacting Partners?
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