PCBD1 and HNF1A

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		PCBD1	HNF1A
Description		pterin-4 alpha-carbinolamine dehydratase 1	HNF1 homeobox A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Extracellular Exosome	Chromatin Nucleus Cytoplasm Protein-containing Complex
	Molecular Function	Transcription Coactivator Activity Phenylalanine 4-monooxygenase Activity Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Identical Protein Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity
	Biological Process	L-phenylalanine Catabolic Process Tetrahydrobiopterin Biosynthetic Process Regulation Of Protein Binding Positive Regulation Of Transcription, DNA-templated	Liver Development Regulation Of Transcription By RNA Polymerase II Insulin Secretion Pancreas Development Regulation Of Pronephros Size Renal Glucose Absorption Glucose Homeostasis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Glucose Import Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter
Pathways		Phenylalanine metabolism	Regulation of gene expression in beta cells
Drugs		L-erythro-7,8-dihydrobiopterin	D-norleucine
Diseases		Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient	Maturity onset diabetes of the young (MODY)
GWAS		Blood protein levels ( 30072576) Chronotype ( 30696823) Immature fraction of reticulocytes ( 27863252) Microalbuminuria ( 26631737) Obesity-related traits ( 23251661)	Acute insulin response ( 28490609) Apolipoprotein B levels ( 32203549) Asthma (age of onset) ( 31036433) Asthma (childhood onset) ( 31036433) Birth weight ( 31043758) Blood protein levels in cardiovascular risk ( 28369058) Blood urea nitrogen levels ( 29403010) C-reactive protein ( 19567438 21647738 18439548 18439552 21196492 23844046 22939635) C-reactive protein and white blood cell count ( 22788528) C-reactive protein levels ( 24763700 29403010 30388399 21300955) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Ceramide levels (C22:0) ( 32489964) Chloride levels ( 29403010) Cholesterol, total ( 24097068 25961943 20686565) Chronic obstructive pulmonary disease-related biomarkers ( 23144326) Coronary artery disease ( 32469254 29212778 30104761 28714974 33020668) Coronary heart disease ( 19198612) Gallstone disease ( 30504769) Gamma glutamyl transferase levels ( 29403010 22010049) Gamma glutamyl transpeptidase ( 21909109) Glucosuria ( 30476138) Glucosuria (moderate to severe) ( 30476138) HDL cholesterol levels ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hemoglobin levels ( 32327693) Homocysteine levels ( 23824729) Insulinogenic index ( 23263489) LDL cholesterol ( 24097068 19060906 30275531 25961943 20686565) LDL cholesterol levels ( 32203549 28334899 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Liver enzyme levels ( 18940312) Liver enzyme levels (gamma-glutamyl transferase) ( 22001757) Longevity ( 20834067) Low density lipoprotein cholesterol levels ( 32154731) N-glycan levels ( 21908519 21203500) Pancreatic cancer ( 29422604 26098869) Pancreatic ductal adenocarcinoma ( 30541042) Peak insulin response ( 28490609) Serum alkaline phosphatase levels ( 31666285) Serum alpha1-antitrypsin levels ( 26174136) Serum metabolite levels (CMS) ( 31636271) Total cholesterol levels ( 28334899 30275531) Type 2 diabetes ( 21573907 22885922 24509480 30297969 29632382 26818947 32499647 20581827 30718926 28869590) Type 2 diabetes (adjusted for BMI) ( 29632382) Urate levels ( 31578528 23263486) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		54 interacting genes: ACIN1 APP BRD7 CACNA1C CALCOCO1 CDK5RAP2 CEBPZ DENND4A DIP2C DVL2 DYRK1B EHMT1 FXR2 GORASP2 GTF3C3 HES4 HNF1A HNF1B HNF4A KANK2 KLF13 LNX1 MIS18BP1 NFKB1 NIF3L1 NTAQ1 NUDT18 PAH PAPOLG PCBD2 PICK1 POLR3A PSMA1 RBL2 RPS24 SAP30 SCMH1 SDCBP SMARCD1 SOWAHC SUPT5H TFF3 TIMELESS TRIM5 WWP1 ZBTB25 ZNF195 ZNF202 ZNF23 ZNF263 ZNF451 ZNF567 ZNF688 ZNF714	24 interacting genes: ALB BCR CDX2 CEBPA CREBBP CTNNB1 EP300 FOS GATA5 HNF1B HNF4A KAT2B MYOG NCOA1 NCOA3 PCBD1 POU2F1 RAC3 RNF14 RYR3 SRC STAT3 TLE1 TLE5
Entrez ID		5092	6927
HPRD ID		00523	00800
Ensembl ID		ENSG00000166228	ENSG00000135100
Uniprot IDs		P61457	E0YMI7 P20823
PDB IDs			1IC8 2GYP
Enriched GO Terms of Interacting Partners?
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