PCBD1 and PAPOLG

Data Source:
BioGRID (two hybrid)

		PCBD1	PAPOLG
Description		pterin-4 alpha-carbinolamine dehydratase 1	poly(A) polymerase gamma
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Extracellular Exosome	Nucleus Nucleoplasm Cytosol Membrane Nuclear Body
	Molecular Function	Transcription Coactivator Activity Phenylalanine 4-monooxygenase Activity Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Identical Protein Binding	RNA Binding Polynucleotide Adenylyltransferase Activity ATP Binding Metal Ion Binding
	Biological Process	L-phenylalanine Catabolic Process Tetrahydrobiopterin Biosynthetic Process Regulation Of Protein Binding Positive Regulation Of Transcription, DNA-templated	MRNA Polyadenylation RNA Polyadenylation
Pathways		Phenylalanine metabolism
Drugs		L-erythro-7,8-dihydrobiopterin
Diseases		Phenylketonuria (PKU); Hyperphenylalaninemia, BH4-deficient
GWAS		Blood protein levels ( 30072576) Chronotype ( 30696823) Immature fraction of reticulocytes ( 27863252) Microalbuminuria ( 26631737) Obesity-related traits ( 23251661)	Acne (severe) ( 24927181) Asthma ( 32296059) Composite immunoglobulin trait (IgA/IgM) ( 28628107) Crohn's disease ( 22412388) Erectile dysfunction ( 30583798) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Systemic lupus erythematosus ( 28714469)
Interacting Genes		54 interacting genes: ACIN1 APP BRD7 CACNA1C CALCOCO1 CDK5RAP2 CEBPZ DENND4A DIP2C DVL2 DYRK1B EHMT1 FXR2 GORASP2 GTF3C3 HES4 HNF1A HNF1B HNF4A KANK2 KLF13 LNX1 MIS18BP1 NFKB1 NIF3L1 NTAQ1 NUDT18 PAH PAPOLG PCBD2 PICK1 POLR3A PSMA1 RBL2 RPS24 SAP30 SCMH1 SDCBP SMARCD1 SOWAHC SUPT5H TFF3 TIMELESS TRIM5 WWP1 ZBTB25 ZNF195 ZNF202 ZNF23 ZNF263 ZNF451 ZNF567 ZNF688 ZNF714	3 interacting genes: LZTR1 NFYA PCBD1
Entrez ID		5092	64895
HPRD ID		00523	11420
Ensembl ID		ENSG00000166228	ENSG00000115421
Uniprot IDs		P61457	Q9BWT3
PDB IDs			4LT6
Enriched GO Terms of Interacting Partners?
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