GEMIN4 and TAP1

Data Source:
BioGRID (two hybrid)

		GEMIN4	TAP1
Description		gem nuclear organelle associated protein 4	transporter 1, ATP binding cassette subfamily B member
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Cytosol Cajal Body Membrane Nuclear Body Small Nuclear Ribonucleoprotein Complex SMN Complex SMN-Sm Protein Complex Extracellular Exosome Gemini Of Coiled Bodies	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane Phagocytic Vesicle Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Centriolar Satellite MHC Class I Peptide Loading Complex TAP Complex
	Molecular Function	Protein Binding Ribonucleoprotein Complex Binding	Protein Binding ATP Binding ABC-type Peptide Antigen Transporter Activity ABC-type Peptide Transporter Activity ATPase Activity MHC Class Ib Protein Binding MHC Class I Protein Binding Peptide Antigen Binding ATPase-coupled Transmembrane Transporter Activity Protein Homodimerization Activity ADP Binding TAP1 Binding TAP2 Binding Peptide Transmembrane Transporter Activity
	Biological Process	Spliceosomal SnRNP Assembly RRNA Processing Import Into Nucleus	Adaptive Immune Response Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Defense Response Protein Transport Peptide Transport Viral Process Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Cytosol To Endoplasmic Reticulum Transport Transmembrane Transport Anion Transmembrane Transport Vesicle Fusion With Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Membrane
Pathways		snRNP Assembly	ER-Phagosome pathway ER-Phagosome pathway Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Diseases			Bare lymphocyte syndrome (BLS) type1 Combined immunodeficiencies (CIDs), including the following nine diseases: X-linked hyper IgM syndrome; CD40 deficiency hyper IgM syndrome; Purine nucleoside phosphorylase (PNP) deficiency; Omenn syndrome; MHC deficiency (HLA-class I); MHC deficiency (HLA-class II); Zap-70 deficiency; p56 Lck deficiency; CD8 deficiency
GWAS		Prostate cancer ( 23535732)	Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) IgA nephropathy ( 25305756) Metabolite levels ( 23823483) Nephropathy ( 21399633)
Interacting Genes		55 interacting genes: AGO2 ALPP CALCOCO2 CCDC185 CCT3 CDC20B CERCAM CFP DDX20 DHX9 DMPK FBXL12 FLAD1 GEMIN5 GLYR1 HR KANK2 KARS1 KRTAP13-2 KRTAP13-4 KRTAP15-1 KRTAP2-3 KRTAP2-4 KRTAP9-2 LGALS1 LGALS3 LY86 MORC4 NPPB NUFIP1 PIAS3 PSMB1 PTCD1 PTEN RAD51D RN7SL1 RNU1-1 RNU2-1 S1PR4 SNRPB SNRPD1 SNRPD2 SPG21 SPRY1 SQSTM1 SRRT STXBP2 STXBP3 TAP1 TOP1 UFC1 USP15 USP2 ZNF326 ZNF35	27 interacting genes: AQP6 CHRM3 CREB3 ERGIC3 ERVFRD-1 ESR1 GEMIN4 GPR152 HLA-F HLA-G KRTAP4-12 LCE2C LMNA MDFI MUL1 PDIA3 PSMB5 PSMB8 RNF19B SLC10A1 SLC10A6 SLC35C2 SSMEM1 TAP2 TAPBP TDP2 TMEM14B
Entrez ID		50628	6890
HPRD ID		07370	01359
Ensembl ID		ENSG00000179409	ENSG00000168394
Uniprot IDs		I3L2C7 P57678 Q8WUM5	A0A0S2Z5A6 B7Z7P4 Q03518 X5CKB3
PDB IDs			1JJ7 5U1D
Enriched GO Terms of Interacting Partners?
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