FURIN and LRP1

  • Data Source:
  • HPRD (in vitro, in vivo)

FURIN

LRP1

Description furin, paired basic amino acid cleaving enzyme LDL receptor related protein 1
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Age at first sexual intercourse ( 27089180)
  • anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028)
  • Apolipoprotein A1 levels ( 32203549)
  • Asthma ( 32296059)
  • Autism spectrum disorder or schizophrenia ( 28540026)
  • Birth weight ( 31043758)
  • Brain morphology (MOSTest) ( 32665545)
  • Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203)
  • Coronary artery disease ( 32469254 29212778 26343387)
  • Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975)
  • Daytime sleep phenotypes ( 27126917)
  • Diastolic blood pressure ( 21909115 28739976 27618452)
  • Diastolic blood pressure (cigarette smoking interaction) ( 29455858)
  • Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962)
  • Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
  • General risk tolerance (MTAG) ( 30643258)
  • Hypertension ( 21909115 30487518)
  • Ischemic stroke ( 29531354)
  • Left-handedness ( 32989287)
  • Mean arterial pressure ( 27618448 30487518)
  • Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962)
  • Myocardial infarction ( 26343387)
  • Neutrophil count ( 32888494)
  • Offspring birth weight ( 31043758)
  • Parental lifespan ( 30642433)
  • Parental longevity (combined parental age at death) ( 29227965)
  • Parental longevity (combined parental attained age, Martingale residuals) ( 29227965)
  • Parental longevity (father's attained age) ( 29227965)
  • Risk-taking tendency (4-domain principal component model) ( 30643258)
  • Schizophrenia ( 25056061 29483656 30285260)
  • Stroke ( 29531354)
  • Systolic blood pressure ( 26390057 28135244 21909115 29403010 28739976 27618452)
  • Systolic blood pressure (cigarette smoking interaction) ( 29455858)
  • Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962)
  • Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
  • White blood cell count ( 32888494)
Interacting Genes 28 interacting genes: ABCC6 ADAM19 ADAMTS1 ADAMTS4 AP2M1 BACE1 CNMD COL23A1 DSG3 EDA FLNA FLNC ITM2C LRP1 MMP14 NAGPA NOTCH1 PACS1 PDGFA PMCH PRB4 SERPINB8 SORCS1 SORL1 TNFSF13 VWF ZP3 ZP4 70 interacting genes: A2M ANAPC10 ANKS1B APBA2 APBB1 APOE APP BACE1 BDNF C3 C4BPA CACNA1A CALR CANX CAV1 CC2D1A CCN2 CD82 CTSG DAB1 DAB2 DLG4 EGFR ELANE F8 F9 FURIN GIPC1 GTPBP1 GULP1 HNRNPDL HSP90B1 ITGB1BP1 KAT5 LIPC LPL LRPAP1 LTF MAPK8IP1 MAPK8IP2 MAPRE1 MDK MMP13 MMP14 MMP15 MMP16 MMP17 MTDH NGF NOS1AP NTF3 NTF4 PDGFB PID1 PLAT PLAUR PRKACA PTPN11 RIC8B SCN3A SERPINA1 SERPINE1 SHC1 SKIL SNRNP70 SNX17 SRC SYNJ2BP THBS1 WNT3A
Entrez ID 5045 4035
HPRD ID 00653 00138
Ensembl ID ENSG00000140564 ENSG00000123384
Uniprot IDs A0A024RC70 P09958 Q07954 Q59FG2
PDB IDs 4OMC 4OMD 4RYD 4Z2A 5JMO 5JXG 5JXH 5JXI 5JXJ 5MIM 6A8Y 6EQV 6EQW 6EQX 6HLB 6HLD 6HLE 6HZA 6HZB 6HZC 6HZD 1CR8 1D2L 1J8E 2FYJ 2FYL 2KNX 2KNY
Enriched GO Terms of Interacting Partners?
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