LRP1 and F9

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		LRP1	F9
Description		LDL receptor related protein 1	coagulation factor IX
Image
GO Annotations	Cellular Component	Nucleus Lysosomal Membrane Early Endosome Cytoskeleton Plasma Membrane Integral Component Of Plasma Membrane Clathrin-coated Pit Focal Adhesion Membrane Basolateral Plasma Membrane Clathrin-coated Vesicle Dendrite Endocytic Vesicle Membrane Insulin-responsive Compartment Neuronal Cell Body Receptor Complex Axonal Growth Cone Apical Part Of Cell Plasma Membrane Protein Complex Postsynaptic Golgi Apparatus	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Lumen Plasma Membrane Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Amyloid-beta Binding Protease Binding RNA Binding Low-density Lipoprotein Particle Receptor Activity Scavenger Receptor Activity Calcium Ion Binding Protein Binding Coreceptor Activity Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Clathrin Heavy Chain Binding Apolipoprotein Binding Signaling Receptor Activity Cargo Receptor Activity Heparan Sulfate Proteoglycan Binding Protein-containing Complex Binding Lipoprotein Particle Receptor Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Calcium Ion Binding Protein Binding
	Biological Process	Retinoid Metabolic Process Astrocyte Activation Involved In Immune Response Lipid Metabolic Process Receptor-mediated Endocytosis Phagocytosis Lysosomal Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Aging Cell Population Proliferation Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Cholesterol Efflux Positive Regulation Of Cell Death Negative Regulation Of Neuron Projection Development Negative Regulation Of Smooth Muscle Cell Migration Cerebral Cortex Development Negative Regulation Of Wnt Signaling Pathway Receptor Internalization Positive Regulation Of Protein Binding Positive Regulation Of Lipid Transport Regulation Of Cholesterol Transport Regulation Of Phospholipase A2 Activity Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Aorta Morphogenesis Lipoprotein Metabolic Process Lipoprotein Transport Apoptotic Cell Clearance Negative Regulation Of Neuron Apoptotic Process Cellular Lipid Catabolic Process Transcytosis Positive Regulation Of Endocytosis Positive Regulation Of Axon Extension Involved In Regeneration Positive Regulation Of Collateral Sprouting Of Injured Axon Positive Regulation Of Phagocytosis Negative Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Focal Adhesion Assembly Chemoattraction Of Axon Positive Regulation Of ERK1 And ERK2 Cascade Amyloid-beta Clearance Amyloid-beta Clearance By Transcytosis Amyloid-beta Clearance By Cellular Catabolic Process Transport Across Blood-brain Barrier Positive Regulation Of Schwann Cell Migration Positive Regulation Of Amyloid-beta Clearance Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Cholesterol Import Positive Regulation Of Transcytosis Cellular Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Metallopeptidase Activity Positive Regulation Of Lysosomal Protein Catabolic Process Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway	Proteolysis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Blood Coagulation Blood Coagulation, Intrinsic Pathway Zymogen Activation
Pathways		Scavenging of heme from plasma Retinoid metabolism and transport	Extrinsic Pathway of Fibrin Clot Formation Intrinsic Pathway of Fibrin Clot Formation Gamma-carboxylation of protein precursors Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatus Removal of aminoterminal propeptides from gamma-carboxylated proteins Defective factor IX causes thrombophilia Defective cofactor function of FVIIIa variant Defective F9 variant does not activate FX Defective F9 secretion Defective F9 activation Defective gamma-carboxylation of F9
Drugs		Antihemophilic factor, human recombinant Tenecteplase Coagulation Factor IX (Recombinant) Lanoteplase Coagulation Factor IX Human Lonoctocog alfa Moroctocog alfa	Antihemophilic factor, human recombinant Menadione TTP889 Turoctocog alfa Kappadione Coagulation factor VII human Antihemophilic factor human Emicizumab Lonoctocog alfa Moroctocog alfa Turoctocog alfa pegol
Diseases			Hemophilia; Hemophilia A (HEMA); Hemophilia B (HEMB); von Willebrand disease (VWD)
GWAS		Abdominal aortic aneurysm ( 27899403 22055160) Adult asthma ( 30787307) Asthma ( 31959851 27182965 31619474 29273806) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 28552196) Cervical artery dissection ( 25420145) Coronary artery disease ( 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) HDL cholesterol ( 24097068 20686565) HDL cholesterol levels ( 28334899) Headache ( 29397368) Height ( 31562340) Itch intensity from mosquito bite ( 28199695) Lung function (FEV1/FVC) ( 30804560) Medication use (anilides) ( 31015401) Medication use (antimigraine preparations) ( 31015401) Migraine ( 22683712 27182965 23793025 21666692 27322543) Migraine - clinic-based ( 23793025) Migraine without aura ( 23793025 27322543) Moyamoya disease ( 29273593) Peak expiratory flow ( 30804560) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Pulse pressure ( 30578418) Refractive error ( 32231278) Schizophrenia ( 25056061 29483656) Spontaneous coronary artery dissection ( 32887874 32374345) Triglyceride levels ( 28334899) Triglycerides ( 24097068 25961943 20686565)	Venous thromboembolism ( 31676865)
Interacting Genes		70 interacting genes: A2M ANAPC10 ANKS1B APBA2 APBB1 APOE APP BACE1 BDNF C3 C4BPA CACNA1A CALR CANX CAV1 CC2D1A CCN2 CD82 CTSG DAB1 DAB2 DLG4 EGFR ELANE F8 F9 FURIN GIPC1 GTPBP1 GULP1 HNRNPDL HSP90B1 ITGB1BP1 KAT5 LIPC LPL LRPAP1 LTF MAPK8IP1 MAPK8IP2 MAPRE1 MDK MMP13 MMP14 MMP15 MMP16 MMP17 MTDH NGF NOS1AP NTF3 NTF4 PDGFB PID1 PLAT PLAUR PRKACA PTPN11 RIC8B SCN3A SERPINA1 SERPINE1 SHC1 SKIL SNRNP70 SNX17 SRC SYNJ2BP THBS1 WNT3A	5 interacting genes: F2 F7 F8 GGCX LRP1
Entrez ID		4035	2158
HPRD ID		00138	02385
Ensembl ID		ENSG00000123384	ENSG00000101981
Uniprot IDs		Q07954 Q59FG2	P00740
PDB IDs		1CR8 1D2L 1J8E 2FYJ 2FYL 2KNX 2KNY	1CFH 1CFI 1EDM 1IXA 1MGX 1NL0 1RFN 2WPH 2WPI 2WPJ 2WPK 2WPL 2WPM 3KCG 3LC3 3LC5 4WM0 4WMA 4WMB 4WMI 4WMK 4WN2 4WNH 4YZU 4Z0K 4ZAE 5EGM 5F84 5F85 5F86 5JB8 5JB9 5JBA 5JBB 5JBC 5TNO 5TNT 5VYG 6MV4 6RFK 6X5J 6X5L 6X5P
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?