P2RX7 and EFNB3

Data Source:
BioGRID (two hybrid)

		P2RX7	EFNB3
Description		purinergic receptor P2X 7	ephrin B3
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Nuclear Inner Membrane Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Membrane Bleb Postsynapse	Plasma Membrane Integral Component Of Plasma Membrane Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse Integral Component Of Presynaptic Membrane Integral Component Of Postsynaptic Density Membrane
	Molecular Function	Lipopolysaccharide Binding Purinergic Nucleotide Receptor Activity Extracellularly ATP-gated Cation Channel Activity Signaling Receptor Binding Protein Binding ATP Binding Identical Protein Binding	Virus Receptor Activity Transmembrane-ephrin Receptor Activity Protein Binding Ephrin Receptor Binding
	Biological Process	Regulation Of Sodium Ion Transport Response To Ischemia Cell Surface Receptor Signaling Pathway Blood Coagulation Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Gene Expression Plasma Membrane Phospholipid Scrambling Sensory Perception Of Pain Positive Regulation Of Bone Mineralization Bleb Assembly Positive Regulation Of Interleukin-1 Beta Production Response To ATP Positive Regulation Of Ion Transmembrane Transport Calcium-mediated Signaling Using Extracellular Calcium Source Purinergic Nucleotide Receptor Signaling Pathway Negative Regulation Of MAPK Cascade Negative Regulation Of Bone Resorption Negative Regulation Of Cell Volume Positive Regulation Of Glycolytic Process Pore Complex Assembly Positive Regulation Of Cytoskeleton Organization Regulation Of Killing Of Cells Of Other Organism Membrane Depolarization Excitatory Postsynaptic Potential Calcium Ion Transmembrane Transport Cellular Response To ATP Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Bleb Assembly Cell Surface Receptor Signaling Pathway Involved In Cell-cell Signaling	Cell-cell Signaling Nervous System Development Axon Guidance Adult Walking Behavior Axon Choice Point Recognition T Cell Costimulation Viral Entry Into Host Cell Ephrin Receptor Signaling Pathway Negative Regulation Of Axonogenesis Trans-synaptic Signaling By Trans-synaptic Complex, Modulating Synaptic Transmission
Pathways		Elevation of cytosolic Ca2+ levels Platelet homeostasis The NLRP3 inflammasome The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection	EPH-Ephrin signaling EPH-Ephrin signaling EPHB-mediated forward signaling EPHB-mediated forward signaling Ephrin signaling Ephrin signaling EPH-ephrin mediated repulsion of cells
Drugs		Promethazine
Diseases
GWAS		Birth weight ( 31043758) Chronic obstructive pulmonary disease-related biomarkers ( 23144326)	Alcohol consumption ( 31358974)
Interacting Genes		18 interacting genes: ACTB CASK CYSRT1 EFEMP2 EFNB3 EMP3 HSF2BP KRT31 KRT34 KRTAP10-8 NBPF19 NOTCH2NLA PANX1 PLEKHF2 SVIL TM9SF1 TRIM27 ZNF655	8 interacting genes: AATF ELOC EPHA4 EPHB3 P2RX7 RELN RHBDL2 YWHAZ
Entrez ID		5027	1949
HPRD ID		03977	03804
Ensembl ID		ENSG00000089041	ENSG00000108947
Uniprot IDs		Q99572	Q15768
PDB IDs			4BKF
Enriched GO Terms of Interacting Partners?
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