OXT and PREP

Data Source:
HPRD (in vitro)

		OXT	PREP
Description		oxytocin/neurophysin I prepropeptide	prolyl endopeptidase
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Secretory Granule Terminal Bouton	Nucleus Cytoplasm Cytosol Membrane
	Molecular Function	Neuropeptide Hormone Activity Neurohypophyseal Hormone Activity Protein Binding Oxytocin Receptor Binding	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity Oligopeptidase Activity
	Biological Process	Response To Amphetamine Regulation Of Heart Rate Maternal Aggressive Behavior Signal Transduction G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Heart Development Female Pregnancy Memory Grooming Behavior Response To Sucrose Positive Regulation Of Norepinephrine Secretion Response To Activity Sleep Response To Food Positive Regulation Of Prostaglandin Secretion Response To Estradiol Response To Retinoic Acid Response To Progesterone Response To Prostaglandin E Social Behavior Negative Regulation Of Urine Volume Positive Regulation Of Renal Sodium Excretion Response To Cocaine Hyperosmotic Salinity Response Maternal Behavior Sperm Ejaculation Eating Behavior Drinking Behavior Response To Peptide Hormone Response To Ether Negative Regulation Of Blood Pressure Positive Regulation Of Blood Pressure Positive Regulation Of Ossification Positive Regulation Of Female Receptivity Positive Regulation Of Synaptic Transmission Response To Glucocorticoid Response To CAMP Response To Electrical Stimulus Regulation Of Sensory Perception Of Pain Positive Regulation Of Synapse Assembly Male Mating Behavior Positive Regulation Of Penile Erection Positive Regulation Of Hindgut Contraction Negative Regulation Of Gastric Acid Secretion Positive Regulation Of Uterine Smooth Muscle Contraction Positive Regulation Of Cold-induced Thermogenesis	Proteolysis
Pathways		Vasopressin-like receptors G alpha (q) signalling events
Drugs		Oxytocin	1-Hydroxy-1-Thio-Glycerol S-oxy-L-cysteine Z-Pro-Prolinal Monothioglycerol (6S)-1-chloro-3-[(4-fluorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)pyrrolo[1,2-a]pyrazin-4(6H)-one 1-{3-oxo-3-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propyl}-3-phenylquinoxalin-2(1H)-one 2-{3-[(2S)-4,4-difluoro-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-3-oxopropyl}-isoindole-1,3(2H)-dione
Diseases
GWAS		Blood protein levels ( 30072576) Serum oxytocin levels ( 31361301)	Asthma ( 27611488) Beard thickness ( 26926045) Blood protein levels ( 30072576) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Multiple sclerosis ( 31604244) Response to (pegylated) interferon in HBeAG-positive hepatitis B ( 30715261) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		5 interacting genes: ESR2 KMT2A OXTR PREP TXNDC17	7 interacting genes: AGT BRCA1 KNG1 NTS OXT SNCA TAC1
Entrez ID		5020	5550
HPRD ID		08880	02673
Ensembl ID		ENSG00000101405	ENSG00000085377
Uniprot IDs		P01178 X5D7M6	B2RAH7 P48147
PDB IDs			3DDU
Enriched GO Terms of Interacting Partners?
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