PREP and AGT

Data Source:
HPRD (in vitro)

		PREP	AGT
Description		prolyl endopeptidase	angiotensinogen
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GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Membrane	Extracellular Region Extracellular Space Cytosol Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Endopeptidase Activity Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity Oligopeptidase Activity	Serine-type Endopeptidase Inhibitor Activity Hormone Activity Protein Binding Growth Factor Activity Type 1 Angiotensin Receptor Binding Type 2 Angiotensin Receptor Binding
	Biological Process	Proteolysis	Activation Of MAPK Activity Regulation Of Cell Growth Positive Regulation Of Cytokine Production Kidney Development Blood Vessel Remodeling Regulation Of Blood Volume By Renin-angiotensin Renin-angiotensin Regulation Of Aldosterone Production Regulation Of Renal Output By Angiotensin Maintenance Of Blood Vessel Diameter Homeostasis By Renin-angiotensin Renal System Process G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Coupled To CGMP Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Nitric Oxide Mediated Signal Transduction Cell-cell Signaling Regulation Of Blood Pressure Positive Regulation Of Activation Of Janus Kinase Activity Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Esterification Negative Regulation Of Endopeptidase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Regulation Of Lipid Metabolic Process Regulation Of Vasoconstriction Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of NAD(P)H Oxidase Activity Low-density Lipoprotein Particle Remodeling Regulation Of Renal Sodium Excretion Regulation Of Cell Population Proliferation Vasoconstriction Negative Regulation Of MAP Kinase Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of NF-kappaB Transcription Factor Activity Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Extracellular Matrix Assembly Positive Regulation Of Gap Junction Assembly Regulation Of Cardiac Conduction Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			PPARA activates gene expression Metabolism of Angiotensinogen to Angiotensins Metabolism of Angiotensinogen to Angiotensins Peptide ligand-binding receptors G alpha (q) signalling events G alpha (i) signalling events
Drugs		1-Hydroxy-1-Thio-Glycerol S-oxy-L-cysteine Z-Pro-Prolinal Monothioglycerol (6S)-1-chloro-3-[(4-fluorobenzyl)oxy]-6-(pyrrolidin-1-ylcarbonyl)pyrrolo[1,2-a]pyrazin-4(6H)-one 1-{3-oxo-3-[(2S)-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]propyl}-3-phenylquinoxalin-2(1H)-one 2-{3-[(2S)-4,4-difluoro-2-(pyrrolidin-1-ylcarbonyl)pyrrolidin-1-yl]-3-oxopropyl}-isoindole-1,3(2H)-dione	Zinc Copper Sparsentan Zinc acetate
Diseases			Renal tubular dysgenesis
GWAS		Asthma ( 27611488) Beard thickness ( 26926045) Blood protein levels ( 30072576) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Multiple sclerosis ( 31604244) Response to (pegylated) interferon in HBeAG-positive hepatitis B ( 30715261) T wave morphology restitution during exercise ( 31607149) T wave morphology restitution during exercise (MTAG) ( 31607149) Youthful appearance (self-reported) ( 32339537)	Blood protein levels ( 30072576) Coronary artery disease ( 29212778 33020668) Diastolic blood pressure ( 27841878 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Mean arterial pressure ( 27618448) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Pancreatic ductal adenocarcinoma ( 30541042) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Systolic blood pressure ( 27841878 27618452 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
Interacting Genes		7 interacting genes: AGT BRCA1 KNG1 NTS OXT SNCA TAC1	23 interacting genes: ACE2 AGTR1 AGTR2 ATP6AP2 CMA1 CTSG DNPEP ECE1 ENPEP EWSR1 GRB2 GSDMB ITSN2 KNG1 LNPEP MAS1 MEP1A MME PRCP PREP PRG2 REN TP53
Entrez ID		5550	183
HPRD ID		02673	00106
Ensembl ID		ENSG00000085377	ENSG00000135744
Uniprot IDs		B2RAH7 P48147	B0ZBE2 B2R5S1 P01019
PDB IDs		3DDU	1N9U 1N9V 2JP8 2WXW 2X0B 3CK0 3WOO 3WOR 4AA1 4APH 4FYS 5E2Q 5M3X 5M3Y 5XJM 6I3F 6I3I 6JOD 6OS0 7C6A
Enriched GO Terms of Interacting Partners?
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