OTX2 and NAA50

Data Source:
BioGRID (two hybrid)

		OTX2	NAA50
Description		orthodenticle homeobox 2	N-alpha-acetyltransferase 50, NatE catalytic subunit
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Growth Cone Protein-containing Complex	Nucleus Cytoplasm Cytosol NatA Complex Extracellular Exosome
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Eukaryotic Initiation Factor 4E Binding Sequence-specific Double-stranded DNA Binding	Peptide Alpha-N-acetyltransferase Activity Protein Binding N-acetyltransferase Activity H4 Histone Acetyltransferase Activity Peptidyl-lysine Acetyltransferase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Axon Guidance Regulation Of Smoothened Signaling Pathway Forebrain Development Midbrain Development Positive Regulation Of Embryonic Development Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Assembly Dopaminergic Neuron Differentiation Primitive Streak Formation Positive Regulation Of Gastrulation	N-terminal Protein Amino Acid Acetylation Mitotic Sister Chromatid Cohesion Histone Acetylation Establishment Of Mitotic Sister Chromatid Cohesion Histone H4 Acetylation Mitotic Sister Chromatid Cohesion, Centromeric
Pathways
Drugs
Diseases		Anophthalmia and microphthalmia (A/M) Septo-optic dysplasia
GWAS		Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Chronotype ( 30696823) Moderate-to-late spontaneous preterm birth ( 31194736) Refractive error ( 32231278)	Prostate cancer ( 23535732)
Interacting Genes		43 interacting genes: APP ASIC4 ATP6V1G3 ATXN1 AURKC B4GALNT2 BNIP2 CDK3 CDK4 DMBX1 FOXA2 GPR45 GUCA1B HIKESHI HNF1B HOMER3 HSD3B7 IQGAP1 JPT1 KLF3 LHX1 M1AP MITF NAA50 OR1L3 OR6C1 POLDIP3 RBM47 RNASE11 RPS26 RTCA SMARCB1 SNRPA TBCEL TENT5B TLE4 TMEM11 TNPO2 TRMT10B ZC3H10 ZDHHC17 ZNF765 ZNHIT1	5 interacting genes: BHLHE40 JMJD6 NAA10 NAA15 OTX2
Entrez ID		5015	80218
HPRD ID		07190	14350
Ensembl ID		ENSG00000165588	ENSG00000121579
Uniprot IDs		F1T0C9 F1T0D0 F1T0D1 P32243	E7EQ69 Q9GZZ1
PDB IDs			2OB0 2PSW 3TFY 4X5K 6PPL 6PW9 6WF3 6WF5 6WFG 6WFK 6WFN 6WFO
Enriched GO Terms of Interacting Partners?
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