OTX2 and RNASE11

Data Source:
BioGRID (two hybrid)

		OTX2	RNASE11
Description		orthodenticle homeobox 2	ribonuclease A family member 11 (inactive)
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Growth Cone Protein-containing Complex	Extracellular Region
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Eukaryotic Initiation Factor 4E Binding Sequence-specific Double-stranded DNA Binding	Nucleic Acid Binding Endonuclease Activity Ribonuclease Activity Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Axon Guidance Regulation Of Smoothened Signaling Pathway Forebrain Development Midbrain Development Positive Regulation Of Embryonic Development Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Protein-containing Complex Assembly Dopaminergic Neuron Differentiation Primitive Streak Formation Positive Regulation Of Gastrulation	RNA Phosphodiester Bond Hydrolysis
Pathways
Drugs
Diseases		Anophthalmia and microphthalmia (A/M) Septo-optic dysplasia
GWAS		Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258) Chronotype ( 30696823) Moderate-to-late spontaneous preterm birth ( 31194736) Refractive error ( 32231278)	Food allergy (parent-of-origin effect) ( 29489655) Milk allergy (parent-of-origin effect) ( 29489655)
Interacting Genes		43 interacting genes: APP ASIC4 ATP6V1G3 ATXN1 AURKC B4GALNT2 BNIP2 CDK3 CDK4 DMBX1 FOXA2 GPR45 GUCA1B HIKESHI HNF1B HOMER3 HSD3B7 IQGAP1 JPT1 KLF3 LHX1 M1AP MITF NAA50 OR1L3 OR6C1 POLDIP3 RBM47 RNASE11 RPS26 RTCA SMARCB1 SNRPA TBCEL TENT5B TLE4 TMEM11 TNPO2 TRMT10B ZC3H10 ZDHHC17 ZNF765 ZNHIT1	2 interacting genes: APP OTX2
Entrez ID		5015	122651
HPRD ID		07190	15257
Ensembl ID		ENSG00000165588	ENSG00000173464
Uniprot IDs		F1T0C9 F1T0D0 F1T0D1 P32243	Q5GAN5 Q8TAA1
PDB IDs
Enriched GO Terms of Interacting Partners?
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