CLDN11 and TNFSF14

Data Source:
BioGRID (two hybrid)

		CLDN11	TNFSF14
Description		claudin 11	TNF superfamily member 14
Image		No pdb structure
GO Annotations	Cellular Component	Lipid Droplet Neurofilament Plasma Membrane Bicellular Tight Junction Integral Component Of Membrane Cell Junction Axon Basal Part Of Cell Tight Junction	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Structural Molecule Activity Protein Binding Identical Protein Binding	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Cell Adhesion Spermatogenesis Axon Ensheathment Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Bicellular Tight Junction Assembly Tight Junction Assembly	Apoptotic Process Immune Response Signal Transduction T Cell Costimulation Tumor Necrosis Factor-mediated Signaling Pathway T Cell Proliferation T Cell Activation T Cell Homeostasis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Response To Mechanical Stimulus Positive Regulation Of NIK/NF-kappaB Signaling
Pathways		Tight junction interactions	TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs
Diseases
GWAS		Blood glucose levels ( 31928498) Monocyte chemoattractant protein-1 (red blood cell fatty acid level interaction) ( 28820441) Prostate cancer ( 21743467)	Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Granulocyte percentage of myeloid white cells ( 27863252) Monocyte count ( 29403010) Monocyte percentage of white cells ( 27863252) Multiple sclerosis ( 31604244 24076602 21833088)
Interacting Genes		12 interacting genes: AMIGO1 C16orf54 FNDC9 KLRC1 SHISA3 SMIM3 SPINT1 TMEM80 TNFSF14 TSPAN3 TSPAN4 ZP3	22 interacting genes: ADAM33 ADIPOQ APP BMP10 CLDN11 CLDN19 CXCL9 JAGN1 LHFPL3 LTB LTBR MAL OLFM4 PLLP PTTG1IP SEC22A SEC23A SYS1 TMEM11 TNFRSF14 TNFRSF6B UPK2
Entrez ID		5010	8740
HPRD ID		03207	05157
Ensembl ID		ENSG00000013297	ENSG00000125735
Uniprot IDs		O75508	O43557
PDB IDs			4EN0 4J6G 4KG8 4KGG 4KGQ 4RSU
Enriched GO Terms of Interacting Partners?
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