OPRL1 and RGS19

Data Source:
HPRD (in vitro, in vivo)

		OPRL1	RGS19
Description		opioid related nociceptin receptor 1	regulator of G protein signaling 19
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Vesicle Neuron Projection	Golgi Apparatus Plasma Membrane Brush Border Membrane Clathrin-coated Vesicle Membrane Raft
	Molecular Function	Nociceptin Receptor Activity G Protein-coupled Receptor Activity Protein Binding Peptide Binding Neuropeptide Binding	G-protein Alpha-subunit Binding GTPase Activity Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Sensory Perception Behavior Sensory Perception Of Pain Opioid Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway	Autophagy G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Negative Regulation Of Signal Transduction Response To Ethanol
Pathways		Peptide ligand-binding receptors G alpha (i) signalling events	G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events
Drugs		Buprenorphine Etorphine Epicept NP-1
Diseases
GWAS		Cerebrospinal AB1-42 levels in normal cognition ( 29274321) HDL cholesterol levels ( 32203549) LDL peak particle diameter (total fat intake interaction) ( 26112879) Lymphocyte counts ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 31589552) Monocyte count ( 32888494) Triglyceride levels ( 32203549 32154731)	Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Chronic kidney disease ( 31152163) Coronary artery disease ( 33020668) Estimated glomerular filtration rate ( 31152163) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Systolic blood pressure ( 30578418)
Interacting Genes		10 interacting genes: CERS6 DNAJC30 GNA14 GPRASP1 HLA-C OPRM1 PLLP PNOC RGS19 SLC31A2	25 interacting genes: ALPP CATSPER1 CSNK2A1 CSNK2A2 GDE1 GIPC1 GNAI1 GNAI2 GNAI3 GNAO1 GNAZ HOXA1 KRTAP5-6 LCE4A MAPK1 MAPK6 NUFIP2 OPRL1 OSTM1 OTX1 POU4F2 PRKCA PSMA1 TGFBR1 VASN
Entrez ID		4987	10287
HPRD ID		03971	05461
Ensembl ID		ENSG00000125510	ENSG00000171700
Uniprot IDs		A0A5F9ZI64 P41146 Q8IXB0	B4DP94 P49795
PDB IDs		4EA3 5DHG 5DHH	1CMZ
Enriched GO Terms of Interacting Partners?
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