TRIM72 and MED21

Data Source:
BioGRID (two hybrid)

		TRIM72	MED21
Description		tripartite motif containing 72	mediator complex subunit 21
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoplasmic Vesicle Membrane Sarcolemma	Mediator Complex
	Molecular Function	Phosphatidylserine Binding Protein Binding Zinc Ion Binding Ubiquitin Conjugating Enzyme Binding Identical Protein Binding Ubiquitin Protein Ligase Activity	Transcription Coregulator Activity Transcription Coactivator Activity DNA-directed 5'-3' RNA Polymerase Activity Protein Binding
	Biological Process	Plasma Membrane Repair Muscle System Process Exocytosis Muscle Contraction Muscle Organ Development Negative Regulation Of Myotube Differentiation Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Negative Regulation Of Insulin Receptor Signaling Pathway Protein Homooligomerization	Regulation Of Transcription By RNA Polymerase II RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Smooth Muscle Contraction Smooth Muscle Contraction	PPARA activates gene expression Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS			Dimensional psychopathology (Social) ( 29496196)
Interacting Genes		18 interacting genes: ABI2 C1orf216 INSR IRS1 MED21 MZT1 NMI PPP3CA SMARCD1 TCF12 TRIM32 UBE2C UBE2D3 UBE2H UBE2I UBE2N VSIG4 ZNF655	30 interacting genes: BLOC1S6 BORCS6 BRCA1 BTF3 CDK8 CDK9 ELOA ESR1 ESR2 HGS HNF4A HTT MAGEA6 MAGEB4 MED29 MIEF1 PCBD2 POLR2A SKP1 SSC5D TARBP2 TFG THRA THRB TP53 TRIM27 TRIM72 VAV2 ZNF655 ZSCAN1
Entrez ID		493829	9412
HPRD ID		17412	09156
Ensembl ID		ENSG00000177238	ENSG00000152944
Uniprot IDs		Q6ZMU5	A0A024RAW0 Q13503
PDB IDs		3KB5
Enriched GO Terms of Interacting Partners?
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