OAS1 and RPL30

Data Source:
BioGRID (two hybrid)

		OAS1	RPL30
Description		2'-5'-oligoadenylate synthetase 1	ribosomal protein L30
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GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Membrane	Nucleus Cytosol Focal Adhesion Postsynaptic Density Membrane Cytosolic Large Ribosomal Subunit Polysomal Ribosome Extracellular Exosome
	Molecular Function	2'-5'-oligoadenylate Synthetase Activity Double-stranded RNA Binding Protein Binding ATP Binding Metal Ion Binding	RNA Binding Structural Constituent Of Ribosome Protein Binding Selenocysteine Insertion Sequence Binding
	Biological Process	Glucose Metabolic Process Response To Virus Glucose Homeostasis Negative Regulation Of Viral Genome Replication Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Ribonuclease Activity	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytoplasmic Translation Translation Translational Initiation SRP-dependent Cotranslational Protein Targeting To Membrane Viral Transcription Killing Of Cells Of Other Organism Defense Response To Gram-negative Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Liver Regeneration Positive Regulation Of Selenocysteine Incorporation
Pathways		Interferon gamma signaling OAS antiviral response Interferon alpha/beta signaling	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs		Cysteine-S-acetamide
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Body mass index ( 26426971) Glycemic traits ( 23575436) Low HDL-cholesterol levels ( 31006500) Response to fenofibrate (adiponectin levels) ( 23149075) Right-sided colonic diverticulosis ( 31089239) Urate levels ( 31578528)	Metabolite levels ( 23823483)
Interacting Genes		11 interacting genes: ACTN1 BBS4 BUD23 COG6 EXOC5 GOLGA2 HOOK2 PRMT6 RPL30 RUFY1 TRIM27	14 interacting genes: APP CASP2 DUX4 ERCC6 FAM120B G0S2 IL7R MAP2K7 MAP3K14 NEDD4L NFKB2 OAS1 PTEN ZFAND2A
Entrez ID		4938	6156
HPRD ID		08879	01595
Ensembl ID		ENSG00000089127	ENSG00000156482
Uniprot IDs		P00973	A0A024R9D3 P62888
PDB IDs		4IG8	3VI6 4UG0 4V6X 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO
Enriched GO Terms of Interacting Partners?
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