OAS1 and BUD23

Data Source:
BioGRID (two hybrid)

		OAS1	BUD23
Description		2'-5'-oligoadenylate synthetase 1	BUD23 rRNA methyltransferase and ribosome maturation factor
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GO Annotations	Cellular Component	Extracellular Region Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Membrane	Nucleoplasm Nucleolus Perinuclear Region Of Cytoplasm
	Molecular Function	2'-5'-oligoadenylate Synthetase Activity Double-stranded RNA Binding Protein Binding ATP Binding Metal Ion Binding	RNA Binding Protein Binding Methyltransferase Activity RRNA (guanine) Methyltransferase Activity Protein Heterodimerization Activity
	Biological Process	Glucose Metabolic Process Response To Virus Glucose Homeostasis Negative Regulation Of Viral Genome Replication Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Regulation Of Ribonuclease Activity	Chromatin Organization RRNA Methylation RRNA (guanine-N7)-methylation Positive Regulation Of RRNA Processing
Pathways		Interferon gamma signaling OAS antiviral response Interferon alpha/beta signaling	rRNA modification in the nucleus and cytosol Major pathway of rRNA processing in the nucleolus and cytosol
Drugs		Cysteine-S-acetamide
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Body mass index ( 26426971) Glycemic traits ( 23575436) Low HDL-cholesterol levels ( 31006500) Response to fenofibrate (adiponectin levels) ( 23149075) Right-sided colonic diverticulosis ( 31089239) Urate levels ( 31578528)
Interacting Genes		11 interacting genes: ACTN1 BBS4 BUD23 COG6 EXOC5 GOLGA2 HOOK2 PRMT6 RPL30 RUFY1 TRIM27	4 interacting genes: OAS1 PKN1 TRMT112 VCP
Entrez ID		4938	114049
HPRD ID		08879	15659
Ensembl ID		ENSG00000089127	ENSG00000071462
Uniprot IDs		P00973	O43709
PDB IDs		4IG8	6G4W
Enriched GO Terms of Interacting Partners?
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