ROR2 and DUSP21

Data Source:
BioGRID (two hybrid)

		ROR2	DUSP21
Description		receptor tyrosine kinase like orphan receptor 2	dual specificity phosphatase 21
Image			No pdb structure
GO Annotations	Cellular Component	Microtubule Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Dendrite Clathrin-coated Endocytic Vesicle Membrane Neuronal Cell Body Receptor Complex	Nucleus Cytoplasm Mitochondrial Matrix Extrinsic Component Of Mitochondrial Inner Membrane
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Frizzled Binding Protein Binding ATP Binding Wnt-protein Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Metal Ion Binding Coreceptor Activity Involved In Wnt Signaling Pathway, Planar Cell Polarity Pathway	Protein Tyrosine Phosphatase Activity Protein Binding MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Cartilage Condensation Somitogenesis Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Smoothened Signaling Pathway JNK Cascade Multicellular Organism Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Neuron Projection Development Astrocyte Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Bone Mineralization Positive Regulation Of Cell Migration BMP Signaling Pathway Embryonic Genitalia Morphogenesis Male Genitalia Development Positive Regulation Of Kinase Activity Inner Ear Morphogenesis Embryonic Digit Morphogenesis Positive Regulation Of MAPK Cascade Positive Regulation Of JUN Kinase Activity Cell Fate Commitment Positive Regulation Of Macrophage Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Synaptic Transmission, Glutamatergic Wnt Signaling Pathway, Planar Cell Polarity Pathway SMAD Protein Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Kinase C Activity Macrophage Migration	Inactivation Of MAPK Activity Peptidyl-tyrosine Dephosphorylation
Pathways		PCP/CE pathway WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Drugs
Diseases		Brachydactyly, including: type A; type B; type D; type E Robinow syndrome
GWAS		Bipolar disorder (inflammation and infection response interaction) ( 25781172) Bipolar disorder and schizophrenia ( 22688191) Birth weight ( 31043758) Bone mineral density (hip) ( 26911590) Facial morphology ( 31763980) Iris color (L* coordinate) ( 30895295) Nose size ( 27182965) Offspring birth weight ( 31043758) Serum immune biomarker levels ( 32066700) Type 2 diabetes ( 25483131)
Interacting Genes		74 interacting genes: ALG13 ARID5A ATXN7L1 BHLHE40 C10orf55 C19orf54 C1orf94 C3orf56 CDC14A CDC25C CREM CRX DAB1 DAZAP2 DUSP1 DUSP10 DUSP14 DUSP18 DUSP19 DUSP21 DUSP29 DUSP6 ERBB2 EYA2 FAM168B FOSB FZD2 FZD5 HIVEP1 IKBKG ILKAP ISX KRTAP19-7 KRTAP6-2 KRTAP7-1 LHX6 MAGED1 MAP3K7 MSX2 MTMR1 MTMR2 MTMR6 MTMR9 PITX1 PLA2G10 POU2AF1 PPM1A PPM1B PPM1F PPP3CB PRKAB2 PRR20A PRR20B PRR20C PRR20D PRR20E PTPN11 PTPN12 PTPN20 PTPN6 PTPN7 PTPRR RBPMS SOX14 STOX1 STYX TAB1 TENT5A TLX3 TPTE VENTX WNT5A ZMYM4 ZNF34	33 interacting genes: APP ATP23 BPIFA1 CPNE7 CTBP2 EPHA3 EPHA5 ERBB3 ERBB4 EYA2 FAAP20 GET4 GORASP2 IGF1R KLHL20 KRT33B KRTAP11-1 MAP2K5 MYO15B OIP5 POU4F3 PTK7 RFX6 RGS2 ROR1 ROR2 SUOX TEX11 TOX3 TRAF1 UBQLN2 USP2 ZMAT1
Entrez ID		4920	63904
HPRD ID		03822	06494
Ensembl ID		ENSG00000169071	ENSG00000189037
Uniprot IDs		Q01974	Q9H596
PDB IDs		3ZZW 4GT4 6OSH 6OSN 6OSV
Enriched GO Terms of Interacting Partners?
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