ROR2 and KRTAP6-2

Data Source:
BioGRID (two hybrid)

		ROR2	KRTAP6-2
Description		receptor tyrosine kinase like orphan receptor 2	keratin associated protein 6-2
Image			No pdb structure
GO Annotations	Cellular Component	Microtubule Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Dendrite Clathrin-coated Endocytic Vesicle Membrane Neuronal Cell Body Receptor Complex	Cytosol Intermediate Filament
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Frizzled Binding Protein Binding ATP Binding Wnt-protein Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Metal Ion Binding Coreceptor Activity Involved In Wnt Signaling Pathway, Planar Cell Polarity Pathway	Protein Binding Identical Protein Binding
	Biological Process	Cartilage Condensation Somitogenesis Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Smoothened Signaling Pathway JNK Cascade Multicellular Organism Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Neuron Projection Development Astrocyte Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Phosphorylation Bone Mineralization Positive Regulation Of Cell Migration BMP Signaling Pathway Embryonic Genitalia Morphogenesis Male Genitalia Development Positive Regulation Of Kinase Activity Inner Ear Morphogenesis Embryonic Digit Morphogenesis Positive Regulation Of MAPK Cascade Positive Regulation Of JUN Kinase Activity Cell Fate Commitment Positive Regulation Of Macrophage Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Synaptic Transmission, Glutamatergic Wnt Signaling Pathway, Planar Cell Polarity Pathway SMAD Protein Signal Transduction Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Protein Kinase C Activity Macrophage Migration	Keratinization
Pathways		PCP/CE pathway WNT5A-dependent internalization of FZD2, FZD5 and ROR2	Keratinization
Drugs
Diseases		Brachydactyly, including: type A; type B; type D; type E Robinow syndrome
GWAS		Bipolar disorder (inflammation and infection response interaction) ( 25781172) Bipolar disorder and schizophrenia ( 22688191) Birth weight ( 31043758) Bone mineral density (hip) ( 26911590) Facial morphology ( 31763980) Iris color (L* coordinate) ( 30895295) Nose size ( 27182965) Offspring birth weight ( 31043758) Serum immune biomarker levels ( 32066700) Type 2 diabetes ( 25483131)
Interacting Genes		74 interacting genes: ALG13 ARID5A ATXN7L1 BHLHE40 C10orf55 C19orf54 C1orf94 C3orf56 CDC14A CDC25C CREM CRX DAB1 DAZAP2 DUSP1 DUSP10 DUSP14 DUSP18 DUSP19 DUSP21 DUSP29 DUSP6 ERBB2 EYA2 FAM168B FOSB FZD2 FZD5 HIVEP1 IKBKG ILKAP ISX KRTAP19-7 KRTAP6-2 KRTAP7-1 LHX6 MAGED1 MAP3K7 MSX2 MTMR1 MTMR2 MTMR6 MTMR9 PITX1 PLA2G10 POU2AF1 PPM1A PPM1B PPM1F PPP3CB PRKAB2 PRR20A PRR20B PRR20C PRR20D PRR20E PTPN11 PTPN12 PTPN20 PTPN6 PTPN7 PTPRR RBPMS SOX14 STOX1 STYX TAB1 TENT5A TLX3 TPTE VENTX WNT5A ZMYM4 ZNF34	185 interacting genes: ADAM12 ADAMTSL4 ANAPC11 ANKS1A ANXA11 APOBEC1 AQP1 ARID5A ATG9A ATN1 ATPAF2 BEX2 BHLHE40 C10orf55 C1orf94 C20orf85 C6orf15 CAMK2A CAMK2B CASC3 CATSPER1 CCDC120 CCDC17 CCDC28A-AS1 CCER1 CCNK CELF5 CERCAM CERK CFP CHIC2 COL8A1 CREB5 CTRC CYSRT1 DAZAP2 DHRS1 DMRT3 ENKD1 ESR2 FAAP20 FAM166B FAM168A FAM214B FAM83A FOXD2 FOXD4L1 FOXD4L3 FOXP3 FRS3 GALT GATA3 GCM2 GLIS2 GLYCTK GNE GPS2 GRINA GRN GSTP1 HAPLN2 HELT HEY1 HEY2 HEYL HHEX HOXA1 HOXB9 HOXC8 HOXC9 HSF4 HYAL2 IGFN1 INCA1 INO80B ITGB4 KLHL38 KPRP KRT83 KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-3 KRTAP12-4 KRTAP15-1 KRTAP19-5 KRTAP26-1 KRTAP3-3 KRTAP4-11 KRTAP4-12 KRTAP6-1 KRTAP6-3 LASP1 LCE2B LCE2D LCE5A LETM1 LGALS9C LRFN4 LRRC41 LYVE1 MEIS2 MGAT5B MKRN3 NAF1 NDUFA9 NEU4 NFKBID NID2 NPBWR2 NR1D2 NSD1 OLIG3 OTX1 PATL1 PATZ1 PAX3 PDP1 PHLDA1 PITX1 PKD2 PLEKHN1 PLSCR4 POGZ POU5F2 PPP1R32 PRR13 PRR3 PRR30 PRR35 RASD1 RBFOX2 RBPMS2 RERE RHOXF2 RNF38 ROR2 RTP5 RUNX1T1 RUSC1 SAMD7 SHARPIN SIAH3 SMAP2 SMARCC1 SMN1 SMN2 SMUG1 SNRPB SNRPC SPAG8 SPATA8 TBX6 TCF7L2 TEKT3 TEKT4 TEKT5 TENT5B TENT5D TEPSIN TEX37 TFAP2D TLE5 TLX2 TLX3 TNIP1 TOLLIP TPRX1 TRIP13 TSGA10IP TSPAN4 TSPYL6 VAC14 VENTX VGLL3 VPS37C YPEL3 ZBTB32 ZC3H10 ZIC1 ZNF414 ZNF503 ZNF581 ZNF683 ZNF843
Entrez ID		4920	337967
HPRD ID		03822	11219
Ensembl ID		ENSG00000169071	ENSG00000186930
Uniprot IDs		Q01974	Q3LI66
PDB IDs		3ZZW 4GT4 6OSH 6OSN 6OSV
Enriched GO Terms of Interacting Partners?
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