NTHL1 and ERCC5

Data Source:
HPRD (in vitro)

		NTHL1	ERCC5
Description		nth like DNA glycosylase 1	ERCC excision repair 5, endonuclease
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mitochondrion	Nucleotide-excision Repair Complex Nucleus Nucleoplasm DNA Replication Factor A Complex
	Molecular Function	Oxidized Pyrimidine Nucleobase Lesion DNA N-glycosylase Activity Double-stranded DNA Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Endonuclease Activity Protein Binding Oxidized Purine Nucleobase Lesion DNA N-glycosylase Activity DNA N-glycosylase Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity	Bubble DNA Binding RNA Polymerase II Complex Binding Double-stranded DNA Binding Single-stranded DNA Binding Endodeoxyribonuclease Activity Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Metal Ion Binding Protein N-terminus Binding
	Biological Process	Base-excision Repair, AP Site Formation Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Depyrimidination	Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, Preincision Complex Assembly Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Response To UV UV Protection Response To UV-C Nucleotide-excision Repair, DNA Incision Negative Regulation Of Apoptotic Process
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Displacement of DNA glycosylase by APEX1 Defective NTHL1 substrate processing Defective NTHL1 substrate binding	Formation of Incision Complex in GG-NER Dual Incision in GG-NER Dual incision in TC-NER
Drugs
Diseases			Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Adult body size ( 32376654) Longevity ( 20834067)	Apolipoprotein A1 levels ( 32203549) Metabolite levels ( 23823483) Urinary calcium excretion ( 31993563)
Interacting Genes		4 interacting genes: ERCC5 PCNA SRPK2 TP53	12 interacting genes: BRCA1 BRCA2 ERCC2 ERCC6 EWSR1 GTF2H1 GTF2H4 HSPB1 NTHL1 PCNA POLR2A RAD51
Entrez ID		4913	2073
HPRD ID		04039	00595
Ensembl ID		ENSG00000065057	ENSG00000134899
Uniprot IDs		E5KTI5 P78549	P28715
PDB IDs			5EKF 5EKG 6VBH
Enriched GO Terms of Interacting Partners?
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