ERCC5 and NTHL1

Data Source:
HPRD (in vitro)

		ERCC5	NTHL1
Description		ERCC excision repair 5, endonuclease	nth like DNA glycosylase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleus Nucleoplasm DNA Replication Factor A Complex	Nucleus Nucleoplasm Mitochondrion
	Molecular Function	Bubble DNA Binding RNA Polymerase II Complex Binding Double-stranded DNA Binding Single-stranded DNA Binding Endodeoxyribonuclease Activity Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Metal Ion Binding Protein N-terminus Binding	Oxidized Pyrimidine Nucleobase Lesion DNA N-glycosylase Activity Double-stranded DNA Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Endonuclease Activity Protein Binding Oxidized Purine Nucleobase Lesion DNA N-glycosylase Activity DNA N-glycosylase Activity Metal Ion Binding 4 Iron, 4 Sulfur Cluster Binding Class I DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity
	Biological Process	Transcription-coupled Nucleotide-excision Repair Nucleotide-excision Repair Nucleotide-excision Repair, Preincision Complex Stabilization Nucleotide-excision Repair, Preincision Complex Assembly Nucleotide-excision Repair, DNA Incision, 3'-to Lesion Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Response To UV UV Protection Response To UV-C Nucleotide-excision Repair, DNA Incision Negative Regulation Of Apoptotic Process	Base-excision Repair, AP Site Formation Nucleotide-excision Repair, DNA Incision, 5'-to Lesion Depyrimidination
Pathways		Formation of Incision Complex in GG-NER Dual Incision in GG-NER Dual incision in TC-NER	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Displacement of DNA glycosylase by APEX1 Defective NTHL1 substrate processing Defective NTHL1 substrate binding
Drugs
Diseases		Disorders of nucleotide excision repair, including: Xeroderma pigmentosum (XP); Cockayne syndrome (CS); UV-sensitive syndrome (UVS); Trichothiodystrophy (TTD); Cerebro-oculo-facio-skeletal syndrome (COFS); XFE progeroid syndrome
GWAS		Apolipoprotein A1 levels ( 32203549) Metabolite levels ( 23823483) Urinary calcium excretion ( 31993563)	Adult body size ( 32376654) Longevity ( 20834067)
Interacting Genes		12 interacting genes: BRCA1 BRCA2 ERCC2 ERCC6 EWSR1 GTF2H1 GTF2H4 HSPB1 NTHL1 PCNA POLR2A RAD51	4 interacting genes: ERCC5 PCNA SRPK2 TP53
Entrez ID		2073	4913
HPRD ID		00595	04039
Ensembl ID		ENSG00000134899	ENSG00000065057
Uniprot IDs		P28715	E5KTI5 P78549
PDB IDs		5EKF 5EKG 6VBH
Enriched GO Terms of Interacting Partners?
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