ATP2B1 and CCR2

Data Source:
BioGRID (two hybrid)

		ATP2B1	CCR2
Description		ATPase plasma membrane Ca2+ transporting 1	C-C motif chemokine receptor 2
Image
GO Annotations	Cellular Component	Immunological Synapse Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Dendritic Spine Membrane Neuronal Cell Body Membrane Intracellular Membrane-bounded Organelle Membrane Raft Extracellular Exosome Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Presynaptic Active Zone Membrane	Cytoplasm Cytosol Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Dendrite Neuronal Cell Body Perikaryon Perinuclear Region Of Cytoplasm
	Molecular Function	Calcium Transmembrane Transporter Activity, Phosphorylative Mechanism Protein Binding Calmodulin Binding ATP Binding Calcium Ion Transmembrane Transporter Activity ATPase Activity ATPase-coupled Cation Transmembrane Transporter Activity PDZ Domain Binding Metal Ion Binding Calcium-transporting ATPase Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Ion Concentration	Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity C-C Chemokine Binding CCR2 Chemokine Receptor Binding Identical Protein Binding
	Biological Process	Negative Regulation Of Cytokine Production Regulation Of Vascular Associated Smooth Muscle Contraction Neural Retina Development Cellular Calcium Ion Homeostasis Brain Development Aging Regulation Of Blood Pressure Response To Cold Positive Regulation Of Bone Mineralization Ion Transmembrane Transport Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Calcium Ion Transport Cellular Response To Vitamin D Cellular Response To Corticosterone Stimulus Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Cellular Response To Insulin Stimulus Regulation Of Cardiac Conduction Calcium Ion Export Across Plasma Membrane	Blood Vessel Remodeling Dendritic Cell Chemotaxis Regulation Of T Cell Cytokine Production Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Type 2 Immune Response Cellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Immune Response Cellular Defense Response G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Receptor Signaling Pathway Via JAK-STAT Response To Wounding Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of T Cell Chemotaxis Viral Process Negative Regulation Of Angiogenesis Cytokine-mediated Signaling Pathway Sensory Perception Of Pain Calcium-mediated Signaling Cellular Homeostasis Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Tumor Necrosis Factor Production Monocyte Extravasation T-helper 17 Cell Chemotaxis Negative Regulation Of Eosinophil Degranulation Regulation Of T Cell Differentiation Positive Regulation Of Alpha-beta T Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of T Cell Activation Positive Regulation Of Synaptic Transmission, Glutamatergic Cell Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Immune Complex Clearance By Monocytes And Macrophages Inflammatory Response To Wounding Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of NMDA Glutamate Receptor Activity Macrophage Migration Positive Regulation Of Thymocyte Migration Positive Regulation Of Monocyte Extravasation Positive Regulation Of CD8-positive, Alpha-beta T Cell Extravasation Positive Regulation Of Astrocyte Chemotaxis Positive Regulation Of Hematopoietic Stem Cell Migration
Pathways		Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases	Beta defensins Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs		Halothane Desflurane	INCB3284 CCX915 Plozalizumab
Diseases
GWAS		Adult body size ( 32376654) Automobile speeding propensity ( 30643258) Biomedical quantitative traits ( 19396169) Blood pressure ( 24954895 21572416 24001895 21909110) Calcium levels ( 29403010) Chronotype ( 30696823) Coronary artery disease ( 32469254 29212778 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 22751097) Diastolic blood pressure ( 26390057 19430479 27841878 29403010 28739976 27618452 25249183 30487518) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure (long-term average) ( 28348047) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Diffusing capacity of carbon monoxide ( 30694715) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hypertension ( 31513605 31879980 19430479 25249183 28273873 30487518) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Magnesium levels ( 20700443) Mean arterial pressure ( 26390057 29403010 27618448 30487518) Mean arterial pressure (long-term average) ( 28348047) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Morning person ( 30696823) Myocardial infarction ( 26343387) Nonobstructive coronary artery disease ( 26534935) Pulse pressure ( 26390057 27841878 29403010 28739976 30487518 30578418) Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systolic blood pressure ( 30224653 26390057 19430479 27841878 29403010 28739976 27618447 27618452 25249183 30487518 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure (long-term average) ( 28348047) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Total body bone mineral density ( 29304378)	Blood protein levels ( 28240269 23696881) Celiac disease ( 22057235 20190752 25920553 24999842) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 26192919) Monocyte count ( 29403010 27863252) Monocyte percentage of white cells ( 32888494 27863252) Obesity-related traits ( 23251661) Rheumatoid arthritis ( 32868391) Ulcerative colitis ( 26192919 28067908)
Interacting Genes		7 interacting genes: CALM1 CCR2 CSNK2A1 ERBIN F2RL1 PRKACA PRKCA	40 interacting genes: APP ARL6IP5 ATP2B1 B3GAT3 BLOC1S6 CACYBP CD59 CD81 CDIP1 CLPTM1 DMWD EMC10 ERGIC3 GOT1 GPR161 HERPUD1 HMOX2 JPH3 NDFIP1 NOTCH2 NTNG2 PCMT1 PLLP PTPN9 RGR RHOG RTN3 S1PR5 SCG5 SLC2A1 SLC41A3 SRSF5 SUMO1 SVOP TECPR2 TMEM161A TMEM199 TMEM63A TSPAN7 WLS
Entrez ID		490	729230
HPRD ID		00158	19667
Ensembl ID		ENSG00000070961	ENSG00000121807
Uniprot IDs		A0A024RBC7 P20020	A0A024R2Q0 P41597
PDB IDs		6A69	1KAD 1KP1 2MLO 2MLQ 5T1A
Enriched GO Terms of Interacting Partners?
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