ATP2B1 and TRIM32

Data Source:
BioGRID (affinity chromatography technology)

		ATP2B1	TRIM32
Description		ATPase plasma membrane Ca2+ transporting 1	tripartite motif containing 32
Image
GO Annotations	Cellular Component	Immunological Synapse Nucleoplasm Plasma Membrane Integral Component Of Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Dendritic Spine Membrane Neuronal Cell Body Membrane Intracellular Membrane-bounded Organelle Membrane Raft Extracellular Exosome Glutamatergic Synapse GABA-ergic Synapse Integral Component Of Presynaptic Active Zone Membrane	Nucleus Cytoplasm Cytosol Striated Muscle Myosin Thick Filament
	Molecular Function	Calcium Transmembrane Transporter Activity, Phosphorylative Mechanism Protein Binding Calmodulin Binding ATP Binding Calcium Ion Transmembrane Transporter Activity ATPase Activity ATPase-coupled Cation Transmembrane Transporter Activity PDZ Domain Binding Metal Ion Binding Calcium-transporting ATPase Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Ion Concentration	Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Myosin Binding Tat Protein Binding Translation Initiation Factor Binding Identical Protein Binding Ubiquitin Binding Protein Self-association Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Cytokine Production Regulation Of Vascular Associated Smooth Muscle Contraction Neural Retina Development Cellular Calcium Ion Homeostasis Brain Development Aging Regulation Of Blood Pressure Response To Cold Positive Regulation Of Bone Mineralization Ion Transmembrane Transport Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Calcium Ion Transport Cellular Response To Vitamin D Cellular Response To Corticosterone Stimulus Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Cellular Response To Insulin Stimulus Regulation Of Cardiac Conduction Calcium Ion Export Across Plasma Membrane	Protein Polyubiquitination Tissue Homeostasis Ubiquitin-dependent Protein Catabolic Process Actin Ubiquitination Response To UV Protein Ubiquitination Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Regulation Of Type I Interferon Production Negative Regulation Of Viral Transcription Response To Tumor Necrosis Factor Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Fat Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Positive Regulation Of Transcription, DNA-templated Muscle Cell Cellular Homeostasis Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Striated Muscle Cell Differentiation Axon Development Protein K48-linked Ubiquitination Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Interleukin-17-mediated Signaling Pathway Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production Positive Regulation Of Cell Motility
Pathways		Reduction of cytosolic Ca++ levels Ion homeostasis Ion transport by P-type ATPases	Regulation of innate immune responses to cytosolic DNA Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Halothane Desflurane
Diseases			Bardet-Biedl syndrome (BBS)
GWAS		Adult body size ( 32376654) Automobile speeding propensity ( 30643258) Biomedical quantitative traits ( 19396169) Blood pressure ( 24954895 21572416 24001895 21909110) Calcium levels ( 29403010) Chronotype ( 30696823) Coronary artery disease ( 32469254 29212778 26343387 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 22751097) Diastolic blood pressure ( 26390057 19430479 27841878 29403010 28739976 27618452 25249183 30487518) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure (long-term average) ( 28348047) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Diffusing capacity of carbon monoxide ( 30694715) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Hypertension ( 31513605 31879980 19430479 25249183 28273873 30487518) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Magnesium levels ( 20700443) Mean arterial pressure ( 26390057 29403010 27618448 30487518) Mean arterial pressure (long-term average) ( 28348047) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Morning person ( 30696823) Myocardial infarction ( 26343387) Nonobstructive coronary artery disease ( 26534935) Pulse pressure ( 26390057 27841878 29403010 28739976 30487518 30578418) Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Systolic blood pressure ( 30224653 26390057 19430479 27841878 29403010 28739976 27618447 27618452 25249183 30487518 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure (long-term average) ( 28348047) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Total body bone mineral density ( 29304378)	Estimated glomerular filtration rate ( 31015462)
Interacting Genes		7 interacting genes: CALM1 CCR2 CSNK2A1 ERBIN F2RL1 PRKACA PRKCA	63 interacting genes: ABI2 AKTIP ATXN1 CLIP4 DERL1 ERGIC3 FADS6 GABARAP GABARAPL1 GABARAPL2 GEM GLIS2 GPR137B HSPA4 ICMT IQCB1 IRAK1 KCTD9 LCN2 MAP1LC3A MAP1LC3B MAP1LC3C MID2 MOB1A MYCN NDRG2 NTAQ1 PDE9A PELI2 PIAS3 PIAS4 PTCD2 PTPN11 RAB29 RABAC1 RNF208 RNF41 SCGB1A1 SDCBP STING1 SYT6 TCEANC TOP1 TRIM23 TRIM27 TRIM5 TRIM72 TTC23 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2U UBE2V1 UBQLN1 UBQLN2 UBQLN4 VPS11 XIAP
Entrez ID		490	22954
HPRD ID		00158	03797
Ensembl ID		ENSG00000070961	ENSG00000119401
Uniprot IDs		A0A024RBC7 P20020	A0A024R843 Q13049
PDB IDs		6A69	2CT2 5FEY
Enriched GO Terms of Interacting Partners?
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