TRIM32 and IQCB1

Data Source:
BioGRID (pull down)

		TRIM32	IQCB1
Description		tripartite motif containing 32	IQ motif containing B1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Striated Muscle Myosin Thick Filament	Photoreceptor Outer Segment Nucleoplasm Centrosome Centriole Cytosol Cilium Microtubule Cytoskeleton Photoreceptor Connecting Cilium Intercellular Bridge Extracellular Exosome Mitotic Spindle
	Molecular Function	Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Myosin Binding Tat Protein Binding Translation Initiation Factor Binding Identical Protein Binding Ubiquitin Binding Protein Self-association Ubiquitin Protein Ligase Activity	Protein Binding Calmodulin Binding Enzyme Binding
	Biological Process	Protein Polyubiquitination Tissue Homeostasis Ubiquitin-dependent Protein Catabolic Process Actin Ubiquitination Response To UV Protein Ubiquitination Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Regulation Of Type I Interferon Production Negative Regulation Of Viral Transcription Response To Tumor Necrosis Factor Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Fat Cell Differentiation Positive Regulation Of Neuron Differentiation Positive Regulation Of Protein Catabolic Process Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Positive Regulation Of Transcription, DNA-templated Muscle Cell Cellular Homeostasis Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Neurogenesis Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Striated Muscle Cell Differentiation Axon Development Protein K48-linked Ubiquitination Negative Regulation Of Viral Release From Host Cell Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Interleukin-17-mediated Signaling Pathway Positive Regulation Of Chemokine (C-C Motif) Ligand 20 Production Positive Regulation Of Cell Motility	Photoreceptor Cell Maintenance Maintenance Of Animal Organ Identity Cilium Assembly Ciliary Basal Body-plasma Membrane Docking
Pathways		Regulation of innate immune responses to cytosolic DNA Antigen processing: Ubiquitination & Proteasome degradation	Anchoring of the basal body to the plasma membrane
Drugs
Diseases		Bardet-Biedl syndrome (BBS)	Senior-Loken syndrome
GWAS		Estimated glomerular filtration rate ( 31015462)	Hemoglobin levels ( 32327693) Multiple sclerosis ( 31604244 24076602) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376)
Interacting Genes		63 interacting genes: ABI2 AKTIP ATXN1 CLIP4 DERL1 ERGIC3 FADS6 GABARAP GABARAPL1 GABARAPL2 GEM GLIS2 GPR137B HSPA4 ICMT IQCB1 IRAK1 KCTD9 LCN2 MAP1LC3A MAP1LC3B MAP1LC3C MID2 MOB1A MYCN NDRG2 NTAQ1 PDE9A PELI2 PIAS3 PIAS4 PTCD2 PTPN11 RAB29 RABAC1 RNF208 RNF41 SCGB1A1 SDCBP STING1 SYT6 TCEANC TOP1 TRIM23 TRIM27 TRIM5 TRIM72 TTC23 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2U UBE2V1 UBQLN1 UBQLN2 UBQLN4 VPS11 XIAP	12 interacting genes: CALM2 CALML3 KIF9 LDOC1 MARCHF7 MNS1 PCMT1 PDE9A SESTD1 SMARCD1 SPG21 TRIM32
Entrez ID		22954	9657
HPRD ID		03797	11049
Ensembl ID		ENSG00000119401	ENSG00000173226
Uniprot IDs		A0A024R843 Q13049	Q15051
PDB IDs		2CT2 5FEY
Enriched GO Terms of Interacting Partners?
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