NPPA and EPB41

Data Source:
BioGRID (pull down)

		NPPA	EPB41
Description		natriuretic peptide A	erythrocyte membrane protein band 4.1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Protein-containing Complex Cell Projection Perikaryon Collagen-containing Extracellular Matrix	Cytosol Cytoskeleton Plasma Membrane Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Spectrin-associated Cytoskeleton Basolateral Plasma Membrane Nuclear Body Cell Junction Cortical Cytoskeleton Protein-containing Complex Intercellular Bridge Mitotic Spindle Cell Cortex Region
	Molecular Function	Signaling Receptor Binding Hormone Activity Neuropeptide Hormone Activity Protein Binding Hormone Receptor Binding Neuropeptide Receptor Binding	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Calmodulin Binding 1-phosphatidylinositol Binding Protein C-terminus Binding Spectrin Binding Protein N-terminus Binding Phosphoprotein Binding
	Biological Process	Negative Regulation Of Systemic Arterial Blood Pressure Aortic Valve Morphogenesis CGMP Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Protein Folding Receptor Guanylyl Cyclase Signaling Pathway Neuropeptide Signaling Pathway Female Pregnancy Regulation Of Blood Pressure Positive Regulation Of Heart Rate CGMP-mediated Signaling Response To Muscle Stretch Vasodilation Negative Regulation Of JUN Kinase Activity Cellular Protein Metabolic Process Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization Positive Regulation Of Cardiac Muscle Contraction Regulation Of High Voltage-gated Calcium Channel Activity Positive Regulation Of Delayed Rectifier Potassium Channel Activity Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Positive Regulation Of Potassium Ion Export Across Plasma Membrane Regulation Of Cardiac Conduction	Cell Cycle Regulation Of Cell Shape Actin Cytoskeleton Organization Cortical Actin Cytoskeleton Organization Actomyosin Structure Organization Positive Regulation Of Protein Binding Cell Division Regulation Of Calcium Ion Transport Protein-containing Complex Assembly Regulation Of Intestinal Absorption Positive Regulation Of Protein Localization To Cell Cortex
Pathways		YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors Amyloid fiber formation	Neurexins and neuroligins
Drugs
Diseases		Atrial fibrillation	Hereditary elliptocytosis (HE)
GWAS		Atrial fibrillation ( 19597492) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Midregional pro atrial natriuretic peptide levels ( 29237677) Psoriasis ( 25854761) Pulse pressure ( 30578418) Systolic blood pressure ( 19430483 30578418) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Tuberculosis ( 29036319)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Mean corpuscular hemoglobin concentration ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Tourette syndrome ( 30818990)
Interacting Genes		14 interacting genes: EPB41 ESR1 HNF4A HSF2BP MAGEA12 MME NPR1 NPR2 NPR3 NR5A2 RORB UBQLN1 UBQLN2 UBQLN4	39 interacting genes: ACTA1 APP BCAM C2CD2L CASK CD44 CENPJ CLNS1A CRYAB DLG1 DRD2 DRD3 EGFR EIF3G EPB42 FKBP2 GDI1 GYPC KPNA2 MACROD1 MYL1 NPPA NUMA1 PRKCB RWDD2B SEC14L1 SLC4A1 SMAD3 SPTAN1 SPTB SPTBN1 TJP2 TPM1 TUBA4A U2AF1 U2AF2 YWHAB YWHAQ ZCCHC10
Entrez ID		4878	2035
HPRD ID		00164	00558
Ensembl ID		ENSG00000175206	ENSG00000159023
Uniprot IDs		P01160	A0A2R8Y7Y3 P11171 Q1WWM3 Q29RX4 Q59F12
PDB IDs		1ANP 1YK0 3N57	1GG3 2RQ1 3QIJ
Enriched GO Terms of Interacting Partners?
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