NOTCH3 and RMI2

Data Source:
BioGRID (pull down)

		NOTCH3	RMI2
Description		notch receptor 3	RecQ mediated genome instability 2
Image
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cell Surface Actin Cytoskeleton Integral Component Of Membrane Receptor Complex	Nucleoplasm Cytosol Nuclear Speck
	Molecular Function	Calcium Ion Binding Protein Binding Signaling Receptor Activity Identical Protein Binding Cadherin Binding	DNA Binding Protein Binding
	Biological Process	Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Axon Guidance Negative Regulation Of Notch Signaling Pathway Regulation Of Developmental Process	DNA Replication DNA Repair Regulation Of Sister Chromatid Segregation Maintenance Of RDNA Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Double-strand Break Repair Via Homologous Recombination
Pathways		Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription Noncanonical activation of NOTCH3	HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint
Drugs
Diseases		Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL)
GWAS		Pulse pressure ( 27841878 30578418) Toxoplasma gondii sag1 antibody levels ( 33204752)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Crohn's disease ( 28067908) HDL cholesterol ( 25961943) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Inflammatory bowel disease ( 28067908 23128233) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Multiple sclerosis ( 24076602) Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Vein graft stenosis in coronary artery bypass grafting ( 25881214)
Interacting Genes		48 interacting genes: ANKRD28 BAG2 BTF3L4 C1QL1 C8orf76 CBFA2T2 CHUK CNTD1 CPNE6 CRIP2 CSNK2B DLL1 EGFL7 FBLN1 GGT6 JAG1 JAG2 KAT2B LINC00839 MAML1 MAML2 MAML3 MPPED2 MTDH MYC NEDD9 PPIA PRR20A PRR20B PRR20C PRR20D PRR20E PSEN1 PSEN2 RBPJ RET RMI2 SCGB3A1 SLC39A1 SNW1 SNX19 SORBS3 SPTLC2 TMEM108 TNNT2 TPT1 WDR25 XKR8	2 interacting genes: FANCM NOTCH3
Entrez ID		4854	116028
HPRD ID		02607	14497
Ensembl ID		ENSG00000074181	ENSG00000175643
Uniprot IDs		Q9UM47	Q96E14
PDB IDs		4ZLP 5CZV 5CZX	3MXN 3NBH 4DAY
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?