NOTCH3 and C1QL1

Data Source:
BioGRID (pull down)

		NOTCH3	C1QL1
Description		notch receptor 3	complement C1q like 1
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cell Surface Actin Cytoskeleton Integral Component Of Membrane Receptor Complex	Cellular_component Collagen Trimer Cytoplasm Synaptic Cleft Climbing Fiber Presynapse
	Molecular Function	Calcium Ion Binding Protein Binding Signaling Receptor Activity Identical Protein Binding Cadherin Binding	Molecular_function Signaling Receptor Binding Protein Binding
	Biological Process	Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Axon Guidance Negative Regulation Of Notch Signaling Pathway Regulation Of Developmental Process	Locomotory Behavior Neuron Remodeling Motor Learning Maintenance Of Synapse Structure
Pathways		Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription Noncanonical activation of NOTCH3
Drugs
Diseases		Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL)
GWAS		Pulse pressure ( 27841878 30578418) Toxoplasma gondii sag1 antibody levels ( 33204752)	Asthma ( 31619474) Blood protein levels ( 30072576) Brain morphology (MOSTest) ( 32665545) Chronotype ( 30696823) Craniofacial microsomia ( 26853712) DNA methylation (variation) ( 23725790) Hip bone mineral density and total body fat mass (bivariate analysis) ( 32963334) White matter hyperintensity burden ( 25663218)
Interacting Genes		48 interacting genes: ANKRD28 BAG2 BTF3L4 C1QL1 C8orf76 CBFA2T2 CHUK CNTD1 CPNE6 CRIP2 CSNK2B DLL1 EGFL7 FBLN1 GGT6 JAG1 JAG2 KAT2B LINC00839 MAML1 MAML2 MAML3 MPPED2 MTDH MYC NEDD9 PPIA PRR20A PRR20B PRR20C PRR20D PRR20E PSEN1 PSEN2 RBPJ RET RMI2 SCGB3A1 SLC39A1 SNW1 SNX19 SORBS3 SPTLC2 TMEM108 TNNT2 TPT1 WDR25 XKR8	1 interacting genes: NOTCH3
Entrez ID		4854	10882
HPRD ID		02607	12712
Ensembl ID		ENSG00000074181	ENSG00000131094
Uniprot IDs		Q9UM47	O75973
PDB IDs		4ZLP 5CZV 5CZX
Enriched GO Terms of Interacting Partners?
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