CNOT4 and KDM5C

Data Source:
BioGRID (enzymatic study)

		CNOT4	KDM5C
Description		CCR4-NOT transcription complex subunit 4	lysine demethylase 5C
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GO Annotations	Cellular Component	Nucleus Cytosol CCR4-NOT Complex	Nucleus Nucleoplasm Cytosol
	Molecular Function	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding	DNA Binding Protein Binding Zinc Ion Binding Histone Demethylase Activity Histone Demethylase Activity (H3-K4 Specific) Histone Demethylase Activity (H3-trimethyl-K4 Specific) Dioxygenase Activity
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening Ubiquitin-dependent Protein Catabolic Process DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Protein Ubiquitination Regulation Of Megakaryocyte Differentiation Protein Autoubiquitination	Chromatin Remodeling Response To Toxic Substance Histone H3-K4 Demethylation Histone H3-K4 Demethylation, Trimethyl-H3-K4-specific Negative Regulation Of Transcription, DNA-templated Rhythmic Process
Pathways		Deadenylation of mRNA TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain	HDMs demethylate histones
Drugs
Diseases			Syndromic X-linked mental retardation with epilepsy or seizures, including: West syndrome (WS); Partington syndrome (PRTS); Proud syndrome (ACCAG); XMR and epilepsy (XMRE); MRXHF1; XMR OPHN1-related (MRXSO) ; XELBD; XMR, Christianson type (MRXSC); Creatine deficiency syndrome (XL-CDS); Renpenning syndrome (RENS1); Epilepsy and mental retardation limited to females (EFMR); Periventricular nodular heterotopia (PVNH); Hydrocephalus (XLH); XMR, JARID1C related (MRXSJ); Boerjeson-Forssman syndrome (BFLS); CK syndrome (CKS)
GWAS		Appendicular lean mass ( 33097823) Heel bone mineral density ( 30598549) Household income (MTAG) ( 31844048) Meat-related diet ( 32066663) Numerical cognitive ability ( 31620175)	Monocyte percentage of white cells ( 32888494)
Interacting Genes		18 interacting genes: CNOT1 CNOT2 CNOT3 CNOT6 CNOT8 EP300 IL36RN KDM5C RBM15 UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2W	4 interacting genes: CALM1 CNOT4 H3C15 SUMO2
Entrez ID		4850	8242
HPRD ID		05369	02442
Ensembl ID		ENSG00000080802	ENSG00000126012
Uniprot IDs		A0A024R776 A0A024R781 A0A024R785 O95628	A0A6M4C8G8 P41229
PDB IDs		1E4U 1UR6	2JRZ 5FWJ
Enriched GO Terms of Interacting Partners?
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