NME2 and HERC3

Data Source:
BioGRID (two hybrid)

		NME2	HERC3
Description		NME/NM23 nucleoside diphosphate kinase 2	HECT and RLD domain containing E3 ubiquitin protein ligase 3
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Extracellular Region Nucleus Cytoplasm Cytosol Intermediate Filament Focal Adhesion Lamellipodium Mitochondrial Membrane Secretory Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Ficolin-1-rich Granule Lumen	Cytosol Cytoplasmic Vesicle
	Molecular Function	DNA Binding Transcription Coactivator Activity Nucleoside Diphosphate Kinase Activity Protein Histidine Kinase Activity Protein Serine/threonine Kinase Activity Fatty Acid Binding Protein Binding ATP Binding Drug Binding GDP Binding Intermediate Filament Binding Enzyme Binding Identical Protein Binding Metal Ion Binding G-quadruplex DNA Binding	Ubiquitin-protein Transferase Activity
	Biological Process	Negative Regulation Of Myeloid Leukocyte Differentiation Nucleoside Diphosphate Phosphorylation GTP Biosynthetic Process UTP Biosynthetic Process CTP Biosynthetic Process Cell Adhesion Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Nucleoside Triphosphate Biosynthetic Process Positive Regulation Of Neuron Projection Development Nucleobase-containing Small Molecule Interconversion Peptidyl-histidine Phosphorylation Cellular Response To Oxidative Stress Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Neutrophil Degranulation Positive Regulation Of Keratinocyte Differentiation Regulation Of Epidermis Development Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Positive Regulation Of Epithelial Cell Proliferation Response To Growth Hormone Cellular Response To Glucose Stimulus Cellular Response To Fatty Acid	Protein Ubiquitination
Pathways		Interconversion of nucleotide di- and triphosphates Neutrophil degranulation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Guanosine-5'-Diphosphate
Diseases
GWAS		Bipolar disorder ( 31043756) Blood protein levels ( 30072576) Height ( 20881960)	Hair greying ( 26926045) Post bronchodilator FEV1/FVC ratio ( 26634245) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		18 interacting genes: BNIPL CTBP1 DNM1 GIT2 HERC3 HERC5 HERC6 MOB4 NME1 NME3 PPP2CA RAB5A RORA RORB SVIL TBXA2R TERF1 VIM	13 interacting genes: CCL22 CD33 HERC6 NME2 SRPK2 TK1 TRIM14 UBA52 UBC UBE2D1 UBE2L3 UBQLN1 UBQLN2
Entrez ID		4831	8916
HPRD ID		01132	16093
Ensembl ID		ENSG00000243678	ENSG00000138641
Uniprot IDs		F6XY72 P22392 Q6FHN3	B4DK41 Q15034
PDB IDs		1NSK 1NUE 3BBB 3BBC 3BBF
Enriched GO Terms of Interacting Partners?
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