NME2 and HERC5

Data Source:
HPRD (in vivo)

		NME2	HERC5
Description		NME/NM23 nucleoside diphosphate kinase 2	HECT and RLD domain containing E3 ubiquitin protein ligase 5
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Extracellular Region Nucleus Cytoplasm Cytosol Intermediate Filament Focal Adhesion Lamellipodium Mitochondrial Membrane Secretory Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Ficolin-1-rich Granule Lumen	Cytoplasm Cytosol Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding Transcription Coactivator Activity Nucleoside Diphosphate Kinase Activity Protein Histidine Kinase Activity Protein Serine/threonine Kinase Activity Fatty Acid Binding Protein Binding ATP Binding Drug Binding GDP Binding Intermediate Filament Binding Enzyme Binding Identical Protein Binding Metal Ion Binding G-quadruplex DNA Binding	RNA Binding Ubiquitin-protein Transferase Activity Protein Binding ISG15 Transferase Activity Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Myeloid Leukocyte Differentiation Nucleoside Diphosphate Phosphorylation GTP Biosynthetic Process UTP Biosynthetic Process CTP Biosynthetic Process Cell Adhesion Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Integrin-mediated Signaling Pathway Nucleoside Triphosphate Biosynthetic Process Positive Regulation Of Neuron Projection Development Nucleobase-containing Small Molecule Interconversion Peptidyl-histidine Phosphorylation Cellular Response To Oxidative Stress Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Neutrophil Degranulation Positive Regulation Of Keratinocyte Differentiation Regulation Of Epidermis Development Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation Positive Regulation Of Epithelial Cell Proliferation Response To Growth Hormone Cellular Response To Glucose Stimulus Cellular Response To Fatty Acid	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Polyubiquitination Protein Ubiquitination Protein Phosphopantetheinylation ISG15-protein Conjugation Negative Regulation Of Type I Interferon Production Innate Immune Response Regulation Of Defense Response To Virus Defense Response To Virus
Pathways		Interconversion of nucleotide di- and triphosphates Neutrophil degranulation	ISG15 antiviral mechanism DDX58/IFIH1-mediated induction of interferon-alpha/beta Negative regulators of DDX58/IFIH1 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Guanosine-5'-Diphosphate
Diseases
GWAS		Bipolar disorder ( 31043756) Blood protein levels ( 30072576) Height ( 20881960)	Pulmonary function decline ( 22424883) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		18 interacting genes: BNIPL CTBP1 DNM1 GIT2 HERC3 HERC5 HERC6 MOB4 NME1 NME3 PPP2CA RAB5A RORA RORB SVIL TBXA2R TERF1 VIM	15 interacting genes: BECN1 CCNA2 CCNB1 CCND1 CCNE1 CDKN1A ERCC2 IRF3 MTDH NME2 PITX2 STK38 UBE2D1 UBE2D2 UBE2L6
Entrez ID		4831	51191
HPRD ID		01132	10502
Ensembl ID		ENSG00000243678	ENSG00000138646
Uniprot IDs		F6XY72 P22392 Q6FHN3	B4DXV3 Q9UII4
PDB IDs		1NSK 1NUE 3BBB 3BBC 3BBF
Enriched GO Terms of Interacting Partners?
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