NEDD8 and UBE2M

Data Source:
HPRD (in vivo, in vitro)

		NEDD8	UBE2M
Description		NEDD8 ubiquitin like modifier	ubiquitin conjugating enzyme E2 M
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome	Nucleus Nucleoplasm Cytosol
	Molecular Function	Protein Binding Protein Tag Ubiquitin Protein Ligase Binding	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding NEDD8 Transferase Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II Cellular Protein Modification Process Proteolysis Ubiquitin-dependent Protein Catabolic Process Cellular Iron Ion Homeostasis Protein Localization Anatomical Structure Morphogenesis Response To Organic Cyclic Compound Protein Ubiquitination Protein Deubiquitination Modification-dependent Protein Catabolic Process Regulation Of Proteolysis Post-translational Protein Modification Protein Neddylation	Cellular Protein Modification Process Protein Phosphopantetheinylation Positive Regulation Of Neuron Apoptotic Process Post-translational Protein Modification Protein Neddylation
Pathways		TGF-beta receptor signaling activates SMADs UCH proteinases Cargo recognition for clathrin-mediated endocytosis Neddylation Iron uptake and transport	TGF-beta receptor signaling activates SMADs Dectin-1 mediated noncanonical NF-kB signaling NIK-->noncanonical NF-kB signaling Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Mean corpuscular volume ( 29403010) Systolic blood pressure (cigarette smoking interaction) ( 26752167)	Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		42 interacting genes: AHR ARIH2 ATXN3 CBLB CDC34 COPS5 COPS6 CTRC CUL1 CUL2 CUL3 CUL4B DNMT3B GARS1 GHR HGS HIF1A HSPA4 N4BP1 NAE1 NUB1 OTUB1 OTUD5 PARP1 POLI PSMA6 PSMD4 PTK2 RAD23A SENP8 SMURF1 TP53 UBA2 UBA3 UBE2K UBE2M UBL7 UBQLN1 UBXN7 UCHL1 UCHL3 YAF2	30 interacting genes: APP CAND1 CBL CPNE1 CPNE2 CPNE4 CUL1 CUL7 DCUN1D1 DCUN1D2 DCUN1D3 DCUN1D4 DCUN1D5 FBXO7 HSPA4 ITCH MARCHF7 NEDD4 NEDD8 PINK1 PRKN RBX1 RNF111 RNF7 SENP8 SMURF1 TERF1 TP53 UBA1 UBA3
Entrez ID		4738	9040
HPRD ID		04412	04414
Ensembl ID		ENSG00000129559	ENSG00000130725
Uniprot IDs		Q15843	A0A024R4T4 P61081
PDB IDs		1NDD 1R4M 1R4N 1XT9 2BKR 2KO3 2N7K 2NVU 3DBH 3DBL 3DBR 3DQV 3GZN 4F8C 4FBJ 4HCP 4P5O 6R7F 6R7I 6TTU	1TT5 1Y8X 2NVU 3TDU 3TDZ 4GAO 4P5O
Enriched GO Terms of Interacting Partners?
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