NDUFV2 and FAM114A2

Data Source:
BioGRID (two hybrid)

		NDUFV2	FAM114A2
Description		NADH:ubiquinone oxidoreductase core subunit V2	family with sequence similarity 114 member A2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Respiratory Chain Complex I Cytosol	Cellular_component
	Molecular Function	Protein Binding NADH Dehydrogenase (ubiquinone) Activity Electron Transfer Activity Metal Ion Binding 2 Iron, 2 Sulfur Cluster Binding	Protein Binding Purine Nucleotide Binding
	Biological Process	Mitochondrial Electron Transport, NADH To Ubiquinone Nervous System Development Mitochondrial Respiratory Chain Complex I Assembly Cardiac Muscle Tissue Development	Biological_process
Pathways		Respiratory electron transport Complex I biogenesis	Signaling by BRAF and RAF fusions
Drugs		NADH
Diseases		Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Cerebral amyloid deposition (PET imaging) ( 26252872) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Platelet distribution width ( 32888494) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Waist circumference adjusted for body mass index ( 28552196)	Apolipoprotein A1 levels ( 32203549) Red cell distribution width ( 32888494 28957414)
Interacting Genes		6 interacting genes: CCNC CRMP1 FAM114A2 GOLM1 KAT5 SP110	11 interacting genes: APP GAD2 MIEF2 NDUFV2 PILRA PTPN9 RAB2A RAB2B SH3GLB1 TBRG4 TTPA
Entrez ID		4729	10827
HPRD ID		02757	12831
Ensembl ID		ENSG00000178127	ENSG00000055147
Uniprot IDs		P19404	A0A140VKG4 B3KTE4 B4DQT0 E7ESJ7 I6L9D5 Q9NRY5
PDB IDs		5XTB 5XTD 5XTH 5XTI
Enriched GO Terms of Interacting Partners?
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