NCF4 and MSN

Data Source:
HPRD (in vivo, in vitro)

		NCF4	MSN
Description		neutrophil cytosolic factor 4	moesin
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Endosome Membrane Membrane Phagolysosome NADPH Oxidase Complex	Uropod Extracellular Space Nucleus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Microvillus Focal Adhesion Cell Surface Basolateral Plasma Membrane Apical Plasma Membrane Filopodium Pseudopodium Microvillus Membrane Vesicle Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Blood Microparticle
	Molecular Function	Protein Binding Superoxide-generating NAD(P)H Oxidase Activity Superoxide-generating NADPH Oxidase Activator Activity Phosphatidylinositol-3-phosphate Binding Molecular Adaptor Activity	Double-stranded RNA Binding Actin Binding Signaling Receptor Binding Structural Constituent Of Cytoskeleton Protein Binding Enzyme Binding Protein Kinase Binding Cell Adhesion Molecule Binding
	Biological Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Superoxide Metabolic Process Phagocytosis Cellular Response To Oxidative Stress Cell Redox Homeostasis Respiratory Burst Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Catalytic Activity	Immunological Synapse Formation Cytoskeleton Organization Leukocyte Cell-cell Adhesion Regulation Of Cell Shape Regulation Of Cell Size Positive Regulation Of Gene Expression Viral Process Gland Morphogenesis Membrane To Membrane Docking Interleukin-12-mediated Signaling Pathway T Cell Proliferation Establishment Of Epithelial Cell Apical/basal Polarity Leukocyte Migration Establishment Of Endothelial Barrier T Cell Aggregation Cellular Response To Testosterone Stimulus Positive Regulation Of Podosome Assembly T Cell Migration Regulation Of Organelle Assembly Positive Regulation Of Protein Localization To Early Endosome Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Lymphocyte Migration Positive Regulation Of Early Endosome To Late Endosome Transport
Pathways		ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases	Recycling pathway of L1 Recycling pathway of L1 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs		Dextromethorphan
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29679657) Asthma ( 32296059) Atopic dermatitis ( 22197932) Crohn's disease ( 28067908) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Inflammatory bowel disease ( 27569725) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Multiple sclerosis ( 31604244 24076602) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252)	Male-pattern baldness ( 28196072)
Interacting Genes		10 interacting genes: CORO1A CYBA CYBB MSN NCF1 NCF2 PRKCD PRKDC TXN XRCC6	31 interacting genes: BCAP31 CD44 CD46 CD93 CDK11B ERBB2 EZR ICAM1 ICAM2 ICAM3 L1CAM LINC01554 LMO2 MYBPC2 NCF1 NCF4 PLEC PPM1A PPM1B PRKCQ ROCK1 SELL SELPLG SLC9A3R1 SMURF1 SPN TERF1 TRIM15 TSC1 VCAM1 VPS11
Entrez ID		4689	4478
HPRD ID		03289	02399
Ensembl ID		ENSG00000100365	ENSG00000147065
Uniprot IDs		A0A494BZS1 Q15080	P26038 V9HWC0
PDB IDs		1H6H 1OEY 1W6X 1W70 1Z9Q 2DYB	1E5W 1EF1 1SGH 6TXQ 6TXS
Enriched GO Terms of Interacting Partners?
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