NCF4 and CORO1A

Data Source:
HPRD (in vitro)

		NCF4	CORO1A
Description		neutrophil cytosolic factor 4	coronin 1A
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Endosome Membrane Membrane Phagolysosome NADPH Oxidase Complex	Immunological Synapse Phagocytic Cup Nucleus Cytoplasm Early Endosome Cytosol Actin Filament Plasma Membrane Cell-cell Junction Membrane Lamellipodium Axon Phagocytic Vesicle Membrane Cortical Actin Cytoskeleton Protein-containing Complex Phagocytic Vesicle Extracellular Exosome Glutamatergic Synapse
	Molecular Function	Protein Binding Superoxide-generating NAD(P)H Oxidase Activity Superoxide-generating NADPH Oxidase Activator Activity Phosphatidylinositol-3-phosphate Binding Molecular Adaptor Activity	RNA Binding Actin Binding Actin Monomer Binding Protein Binding Protein C-terminus Binding Cytoskeletal Protein Binding Myosin Heavy Chain Binding Protein Homodimerization Activity Phosphatidylinositol 3-kinase Binding Actin Filament Binding
	Biological Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Superoxide Metabolic Process Phagocytosis Cellular Response To Oxidative Stress Cell Redox Homeostasis Respiratory Burst Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Catalytic Activity	Immunological Synapse Formation Phagolysosome Assembly Calcium Ion Transport Phagocytosis Actin Filament Organization Regulation Of Cell Shape Cell Migration Actin Cytoskeleton Organization Positive Regulation Of Cell Migration Leukocyte Chemotaxis Negative Regulation Of Vesicle Fusion Cell-substrate Adhesion Uropod Organization Regulation Of Actin Cytoskeleton Organization Nerve Growth Factor Signaling Pathway Positive Regulation Of T Cell Proliferation T Cell Homeostasis Natural Killer Cell Degranulation Negative Regulation Of Neuron Apoptotic Process Innate Immune Response Homeostasis Of Number Of Cells Within A Tissue Positive Chemotaxis Negative Regulation Of Actin Nucleation Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Early Endosome To Recycling Endosome Transport Cellular Response To Interleukin-4
Pathways		ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases	Prevention of phagosomal-lysosomal fusion
Drugs		Dextromethorphan
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29679657) Asthma ( 32296059) Atopic dermatitis ( 22197932) Crohn's disease ( 28067908) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Inflammatory bowel disease ( 27569725) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Multiple sclerosis ( 31604244 24076602) Multiple sclerosis and triglyceride levels (pleiotropy) ( 26920376) Neutrophil percentage of granulocytes ( 27863252) Sum eosinophil basophil counts ( 27863252)	Brain morphology (MOSTest) ( 32665545) Hodgkin's lymphoma ( 30194254) Tonsillectomy ( 27182965 28928442)
Interacting Genes		10 interacting genes: CORO1A CYBA CYBB MSN NCF1 NCF2 PRKCD PRKDC TXN XRCC6	19 interacting genes: ACTB FHL3 FSD2 GIT2 GOLGA2 IFT20 LMO2 MAGEA11 MAGOH NCF4 POLR1C POT1 SMAD3 SMARCD1 SPATA20 STAT3 TAB1 THBS1 YTHDC1
Entrez ID		4689	11151
HPRD ID		03289	05414
Ensembl ID		ENSG00000100365	ENSG00000102879
Uniprot IDs		A0A494BZS1 Q15080	A0A024R611 P31146
PDB IDs		1H6H 1OEY 1W6X 1W70 1Z9Q 2DYB
Enriched GO Terms of Interacting Partners?
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