ATF4 and LDOC1

Data Source:
HPRD (two hybrid)

		ATF4	LDOC1
Description		activating transcription factor 4	LDOC1 regulator of NFKB signaling
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Nuclear Speck Dendrite Membrane Protein-containing Complex Nuclear Periphery Neuron Projection Lewy Body Core ATF4-CREB1 Transcription Factor Complex ATF1-ATF4 Transcription Factor Complex CHOP-ATF4 Complex	Nucleus Nucleoplasm Nucleolus
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Transcription Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein C-terminus Binding CAMP Response Element Binding Protein Binding Protein Kinase Binding Leucine Zipper Domain Binding Sequence-specific DNA Binding Protein Heterodimerization Activity Sequence-specific Double-stranded DNA Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Gluconeogenesis Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Cellular Calcium Ion Homeostasis Gamma-aminobutyric Acid Signaling Pathway Response To Toxic Substance Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Neuron Differentiation Bone Mineralization Endoplasmic Reticulum Unfolded Protein Response Response To Nutrient Levels Negative Regulation Of Translational Initiation In Response To Stress Circadian Regulation Of Gene Expression Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Cellular Response To UV Response To Endoplasmic Reticulum Stress Embryonic Hemopoiesis Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress PERK-mediated Unfolded Protein Response Cellular Response To Glucose Starvation MRNA Transcription By RNA Polymerase II Positive Regulation Of Apoptotic Process Negative Regulation Of Potassium Ion Transport Positive Regulation Of Neuron Apoptotic Process Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Arsenic-containing Substance Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Positive Regulation Of Biomineral Tissue Development Lens Fiber Cell Morphogenesis L-asparagine Metabolic Process Cellular Response To Oxygen-glucose Deprivation Negative Regulation Of Cold-induced Thermogenesis Integrated Stress Response Signaling HRI-mediated Signaling Negative Regulation Of Oxidative Stress-induced Neuron Death Cellular Response To Dopamine Positive Regulation Of Vascular Associated Smooth Muscle Cell Apoptotic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Response To Manganese-induced Endoplasmic Reticulum Stress Positive Regulation Of Sodium-dependent Phosphate Transport	Negative Regulation Of Cell Population Proliferation Cellular Response To Lipopolysaccharide Cellular Response To Muramyl Dipeptide
Pathways		ATF4 activates genes in response to endoplasmic reticulum stress ATF4 activates genes in response to endoplasmic reticulum stress PERK regulates gene expression ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency Response of EIF2AK1 (HRI) to heme deficiency
Drugs		Pseudoephedrine
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Inflammatory bowel disease ( 23128233) Mean corpuscular volume ( 32888494)
Interacting Genes		75 interacting genes: AP1M1 APH1A APP ASB7 ATF2 ATF3 BATF BATF2 BATF3 BFSP2 BTRC CCDC106 CEBPA CEBPB CEBPE CEBPG CEP83 CKAP4 CREB3 CREBBP CREBZF DAPK3 DDIT3 DISC1 DNMT3L EGLN3 EP300 FOS FOSL1 GABBR2 GCC1 GOLGA1 GOLGA8EP GOLGA8F GPS2 GTF2A1L GTF2B GTF2F2 HAUS7 HK3 JDP2 JUN JUNB KAT2B LDOC1 LMNB1 MAF MAFB MAP2K7 MDM2 MPZL2 NAP1L5 NDC80 NEK6 NFE2 NFE2L1 NFE2L2 NFKBIA NLGN3 POLR2C PTCD3 REPS1 RPS6 SAPCD2 SNAP29 SRA1 TARS3 TBP TGM2 TREX2 TRIB3 TRIM24 TTR ZNF212 ZNF226	107 interacting genes: AATF ABLIM1 AEBP2 AP1M1 AQP1 ATF4 ATP6V1G1 BARD1 BEX2 BYSL C1orf109 CCDC33 CCDC85B CDC5L CEBPE CFAP53 CTNNBL1 DPF2 DPPA4 ENKD1 FAM107A FAM110A FAM161A FAM193B FAM50B FAM90A1 FCHSD2 FOSL1 FXR2 GADD45GIP1 GNL3L GPANK1 HAUS1 HDAC4 HGS HOXB5 HOXC8 IKZF3 IKZF5 INPP1 IQCB1 JRK KRT15 KRT18 LATS1 LENG1 LMO2 LNX1 MBD3 MEAF6 MFAP1 MSGN1 MYC MZF1 NOD2 NRIP1 NXF1 PEG10 PLEKHF2 POLL PPP1R18 PRPF18 PRPF31 PSMA1 PSMF1 RAB29 RALBP1 RASSF10 RIBC1 RNF6 RPP25 SCNM1 SDCBP SETD5 SH2D4A SMARCB1 SMARCD1 SUDS3 TASOR2 TBC1D7 TCEANC TEAD4 THAP7 TLE5 TMSB4XP1 TNNT1 TSGA10IP TSNAX TTC23 UBTFL1 UTP14A WDR25 WT1 ZBTB16 ZBTB24 ZFP1 ZGPAT ZNF124 ZNF250 ZNF408 ZNF564 ZNF587 ZNF629 ZNF648 ZNF688 ZNF774 ZNF835
Entrez ID		468	23641
HPRD ID		06817	02322
Ensembl ID		ENSG00000128272	ENSG00000182195
Uniprot IDs		P18848	O95751
PDB IDs		1CI6
Enriched GO Terms of Interacting Partners?
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