NAB1 and EGR1

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		NAB1	EGR1
Description		NGFI-A binding protein 1	early growth response 1
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GO Annotations	Cellular Component	Nucleus	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	Transcription Coregulator Activity Transcription Factor Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Double-stranded Methylated DNA Binding Histone Acetyltransferase Binding Sequence-specific DNA Binding Hemi-methylated DNA-binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Endochondral Ossification Regulation Of Transcription, DNA-templated Schwann Cell Differentiation Myelination Regulation Of Epidermis Development Negative Regulation Of Transcription, DNA-templated	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Response To Ischemia Regulation Of Transcription By RNA Polymerase II Response To Glucose Positive Regulation Of Gene Expression T Cell Differentiation BMP Signaling Pathway Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-1 Beta Production Response To Insulin Circadian Regulation Of Gene Expression Regulation Of Protein Sumoylation Skeletal Muscle Cell Differentiation Regulation Of Apoptotic Process Estrous Cycle Locomotor Rhythm Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hormone Biosynthetic Process Circadian Temperature Homeostasis Type I Interferon Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Interleukin-1-mediated Signaling Pathway Cellular Response To Gamma Radiation Cellular Response To Heparin Cellular Response To Mycophenolic Acid Glomerular Mesangial Cell Proliferation Positive Regulation Of Glomerular Metanephric Mesangial Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Interleukin-8 Positive Regulation Of Neuron Death Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Tau-protein Kinase Activity Regulation Of Progesterone Biosynthetic Process
Pathways		NGF-stimulated transcription EGR2 and SOX10-mediated initiation of Schwann cell myelination	Regulation of PTEN gene transcription Regulation of PTEN gene transcription NGF-stimulated transcription NGF-stimulated transcription Interferon alpha/beta signaling
Drugs
Diseases
GWAS		Autoimmune traits (pleiotropy) ( 30572963) Bone mineral density (Ward's triangle area) ( 27397699) Daytime sleep phenotypes ( 27126917) Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Multiple sclerosis ( 31604244) Polymyositis ( 26362759) Primary biliary cholangitis ( 26394269) Pulse pressure ( 27841878) Rheumatoid arthritis ( 30572963) Systemic lupus erythematosus ( 33536424) Systemic sclerosis ( 31672989) Systemic seropositive rheumatic diseases (Systemic sclerosis or systemic lupus erythematosus or rheumatoid arthritis or idiopathic inflammatory myopathies) ( 30573655) Systolic blood pressure ( 27841878 30578418)	Amyotrophic lateral sclerosis (C9orf72 mutation interaction) ( 22959728) Autism spectrum disorder or schizophrenia ( 28540026) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Schizophrenia ( 28991256 25056061)
Interacting Genes		2 interacting genes: EGR1 POU2AF1	23 interacting genes: CDKN2A CEBPB CRBN CREBBP CSNK2A1 DNMT3L EP300 ERBB3 IL1B JUN MTDH NAB1 NAB2 NFATC1 NFATC2 PITX1 PSMA3 RELA SP1 SRA1 SREBF2 TP53 WT1
Entrez ID		4664	1958
HPRD ID		02881	00549
Ensembl ID		ENSG00000138386	ENSG00000120738
Uniprot IDs		A8K8T1 B4DKG1 B8ZZS2 Q13506	P18146 Q546S1
PDB IDs		2YUF	4R2A 4R2C 4R2D 4X9J 5N14
Enriched GO Terms of Interacting Partners?
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