EGR1 and NFATC2

Data Source:
HPRD (in vitro)

		EGR1	NFATC2
Description		early growth response 1	nuclear factor of activated T cells 2
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Ribonucleoprotein Complex
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Double-stranded Methylated DNA Binding Histone Acetyltransferase Binding Sequence-specific DNA Binding Hemi-methylated DNA-binding Sequence-specific Double-stranded DNA Binding Promoter-specific Chromatin Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Phosphatase Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Response To Ischemia Regulation Of Transcription By RNA Polymerase II Response To Glucose Positive Regulation Of Gene Expression T Cell Differentiation BMP Signaling Pathway Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-1 Beta Production Response To Insulin Circadian Regulation Of Gene Expression Regulation Of Protein Sumoylation Skeletal Muscle Cell Differentiation Regulation Of Apoptotic Process Estrous Cycle Locomotor Rhythm Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hormone Biosynthetic Process Circadian Temperature Homeostasis Type I Interferon Signaling Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Interleukin-1-mediated Signaling Pathway Cellular Response To Gamma Radiation Cellular Response To Heparin Cellular Response To Mycophenolic Acid Glomerular Mesangial Cell Proliferation Positive Regulation Of Glomerular Metanephric Mesangial Cell Proliferation Negative Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Interleukin-8 Positive Regulation Of Neuron Death Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Tau-protein Kinase Activity Regulation Of Progesterone Biosynthetic Process	Negative Regulation Of Transcription By RNA Polymerase II Cytokine Production Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Cellular Response To DNA Damage Stimulus Myotube Cell Development Cell Migration Positive Regulation Of B Cell Proliferation Calcineurin-NFAT Signaling Cascade Fc-epsilon Receptor Signaling Pathway Response To Drug Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II B Cell Receptor Signaling Pathway Positive Regulation Of Myoblast Fusion Negative Regulation Of Vascular Associated Smooth Muscle Cell Differentiation
Pathways		Regulation of PTEN gene transcription Regulation of PTEN gene transcription NGF-stimulated transcription NGF-stimulated transcription Interferon alpha/beta signaling	Calcineurin activates NFAT Calcineurin activates NFAT FCERI mediated Ca+2 mobilization CLEC7A (Dectin-1) induces NFAT activation RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (C9orf72 mutation interaction) ( 22959728) Autism spectrum disorder or schizophrenia ( 28540026) Cerebrospinal AB1-42 levels in Alzheimer's disease dementia ( 29274321) Schizophrenia ( 28991256 25056061)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Asparaginase hypersensitivity in acute lymphoblastic leukemia ( 25987655) Asthma ( 32296059) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494 27863252) Height ( 28552196) Lymphocyte counts ( 32888494) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Molar-incisor hypomineralization ( 23918034) Monocyte count ( 32888494) Self-reported allergy ( 23817569) Sitting height ratio ( 25865494) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30224653) Tourette's syndrome or obsessive-compulsive disorder ( 25158072) Type 2 diabetes ( 32499647 30718926) Urinary uric acid excretion ( 31993563) Weight ( 28552196) White matter microstructure in first episode schizophrenia (right anterior cingulate cortex) ( 28924203)
Interacting Genes		23 interacting genes: CDKN2A CEBPB CRBN CREBBP CSNK2A1 DNMT3L EP300 ERBB3 IL1B JUN MTDH NAB1 NAB2 NFATC1 NFATC2 PITX1 PSMA3 RELA SP1 SRA1 SREBF2 TP53 WT1	18 interacting genes: CREBBP EGR1 EGR4 EP300 FOXP3 IRF2BP2 IRF4 MED31 MEF2D NFATC2IP PIN1 PPP3CB PPP3R1 PRKCZ TAF9 VIM YWHAQ YWHAZ
Entrez ID		1958	4773
HPRD ID		00549	02730
Ensembl ID		ENSG00000120738	ENSG00000101096
Uniprot IDs		P18146 Q546S1	B5B2P4 Q13469
PDB IDs		4R2A 4R2C 4R2D 4X9J 5N14	1A02 1OWR 1P7H 1PZU 1S9K 2AS5 2O93 3QRF
Enriched GO Terms of Interacting Partners?
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