MYO7A and PC

Data Source:
BioGRID (affinity chromatography technology)

		MYO7A	PC
Description		myosin VIIA	pyruvate carboxylase
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GO Annotations	Cellular Component	Photoreceptor Outer Segment Photoreceptor Inner Segment Cytoplasm Lysosomal Membrane Cytosol Microvillus Cell Cortex Actin Cytoskeleton Apical Plasma Membrane Myosin VII Complex Vesicle Photoreceptor Connecting Cilium Stereocilium Melanosome Synapse Stereocilium Base Upper Tip-link Density	Cytoplasm Mitochondrion Mitochondrial Matrix Cytosol
	Molecular Function	Microfilament Motor Activity Protein Binding Calmodulin Binding ATP Binding Protein Domain Specific Binding Spectrin Binding Actin-dependent ATPase Activity Identical Protein Binding ADP Binding Protein N-terminus Binding Actin Filament Binding	Pyruvate Carboxylase Activity Protein Binding ATP Binding Biotin Binding Identical Protein Binding Metal Ion Binding
	Biological Process	Phagolysosome Assembly Intracellular Protein Transport Actin Filament Organization Lysosome Organization Sensory Organ Development Visual Perception Sensory Perception Of Sound Actin Filament-based Movement Vesicle Transport Along Actin Filament Cellular Protein Localization Eye Photoreceptor Cell Development Mechanoreceptor Differentiation Post-embryonic Animal Organ Morphogenesis Sensory Perception Of Light Stimulus Equilibrioception Pigment Granule Transport Auditory Receptor Cell Stereocilium Organization	Pyruvate Metabolic Process Gluconeogenesis Lipid Metabolic Process Biotin Metabolic Process Negative Regulation Of Gene Expression Viral RNA Genome Packaging Positive Regulation By Host Of Viral Release From Host Cell Positive Regulation By Host Of Viral Process
Pathways		The canonical retinoid cycle in rods (twilight vision)	Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency Gluconeogenesis
Drugs			Pyruvic acid Biotin 5-(hexahydro-2-oxo-1H-thieno[3,4-D]imidazol-6-yl)pentanal
Diseases		Usher syndrome (US) Deafness, autosomal dominant Deafness, autosomal recessive	Pyruvate carboxylase deficiency
GWAS		Lewy body disease ( 25188341) Post bronchodilator FEV1/FVC ratio ( 26634245) Tourette syndrome ( 30818990)	Bipolar disorder ( 21926972 31043756) Familial squamous cell lung carcinoma ( 29924316) HIV-1 susceptibility ( 22174851) Urate levels ( 31578528)
Interacting Genes		12 interacting genes: ACTA1 CALM1 CDH23 KEAP1 KHDRBS1 LINC00839 MAP2 MYRIP PRKAR1A USH1C VEZT WHRN	3 interacting genes: GOT1 GOT2 MDH2
Entrez ID		4647	5091
HPRD ID		02043	02032
Ensembl ID		ENSG00000137474	ENSG00000173599
Uniprot IDs		Q13402	A0A024R5C5 P11498
PDB IDs		5MV9	3BG3 3BG9
Enriched GO Terms of Interacting Partners?
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