MTNR1A and HSPA5

Data Source:
HPRD (in vivo)

		MTNR1A	HSPA5
Description		melatonin receptor 1A	heat shock protein family A (Hsp70) member 5
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane Focal Adhesion COP9 Signalosome Cell Surface Membrane Integral Component Of Endoplasmic Reticulum Membrane Midbody Protein-containing Complex Endoplasmic Reticulum Chaperone Complex Melanosome Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding Melatonin Receptor Activity Hormone Binding Organic Cyclic Compound Binding	Calcium Ion Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding Protein Domain Specific Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Ribosome Binding Protein Folding Chaperone Cadherin Binding Unfolded Protein Binding Chaperone Binding Misfolded Protein Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Mating Behavior Circadian Rhythm	Luteolysis ER Overload Response Positive Regulation Of Neuron Projection Development Cerebellum Structural Organization Cerebellar Purkinje Cell Layer Development Substantia Nigra Development Neuron Differentiation Positive Regulation Of Cell Migration Ubiquitin-dependent ERAD Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Posttranslational Protein Targeting To Membrane, Translocation Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein Ubiquitination Cellular Response To Unfolded Protein Protein Folding In Endoplasmic Reticulum Maintenance Of Protein Localization In Endoplasmic Reticulum Cellular Response To Drug IRE1-mediated Unfolded Protein Response PERK-mediated Unfolded Protein Response ATF6-mediated Unfolded Protein Response Protein Refolding Cellular Response To Glucose Starvation Response To Cocaine Negative Regulation Of Apoptotic Process Chaperone Cofactor-dependent Protein Refolding Neuron Apoptotic Process Regulation Of Protein Folding In Endoplasmic Reticulum Cellular Response To Antibiotic Cellular Response To Calcium Ion Cellular Response To Manganese Ion Cellular Response To CAMP Cellular Response To Interleukin-4 Cellular Response To Gamma Radiation Stress Response To Metal Ion Toxin Transport Regulation Of ATF6-mediated Unfolded Protein Response Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of PERK-mediated Unfolded Protein Response Response To Methamphetamine Hydrochloride Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways		Class A/1 (Rhodopsin-like receptors) G alpha (i) signalling events	Platelet degranulation Regulation of HSF1-mediated heat shock response ATF6 (ATF6-alpha) activates chaperones PERK regulates gene expression IRE1alpha activates chaperones ATF6 (ATF6-alpha) activates chaperone genes Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs		Ramelteon Melatonin Resveratrol Agomelatine Tasimelteon	Antihemophilic factor, human recombinant Acetylsalicylic acid Copper Lonoctocog alfa Moroctocog alfa
Diseases
GWAS		Depressive symptoms measurement (somatic complaints domain) ( 26997408) Job-related exhaustion in shift workers ( 28364478) Obesity ( 21552555)	Refractive error ( 32231278)
Interacting Genes		159 interacting genes: ABHD14B ACTB ACTN1 AMOTL2 ANKRD12 ARHGAP28 ASAP3 ASCL1 ATIC ATP5MC3 BAG6 BAZ1A BAZ1B C10orf90 CALR CAND1 CANX CCDC167 CD99 CHD4 CIAO2B CIT CLASP1 CMIP CNP COG1 COL9A2 COMT COX11 CTNNA1 CTPS2 CUL3 CUL7 CYP27C1 CYSRT1 DDHD2 DDX52 DPM1 ECE1 ECE2 EEF1G EMC7 EMD ENO2 EPS15 EXOC1 F8A1 FAM241B FDXR FLNA FN1 FSTL1 GALNS GAPDH GATAD2B GBA2 GEMIN2 GFPT2 GNA11 GNA13 GNAI1 GNAI2 GNAI3 GNB1 GNB4 GPR50 H2AC6 HDAC10 HIVEP2 HMGN2 HMOX2 HNRNPA0 HNRNPH1 HSPA5 IPO9 IRS4 ITPR3 KLHL12 KLHL20 KLHL5 KPNB1 KRTAP1-3 LAPTM4A LIPE LPP LRP3 LRRC59 MAMLD1 MCC MESD MMP2 MMS19 MPDZ MTNR1B MYO9A NAP1L1 NAP1L4 NAP1L5 NASP PAXIP1 PCDHB10 PDIA6 PEX14 PGRMC1 PKD1L2 PPP2R3C PRELID1 PSMD2 PSME4 PTPN13 PTPRD PTX3 RAB10 RAC1 RACK1 RAP1A RBM39 RGS12 RNF2 RNF41 RPL3 RTRAF SLC2A3 SLC30A1 SLC6A3 SLIT1 SNAPIN SOX11 SRI STXBP1 SUCLA2 SURF4 SVEP1 TLN1 TM9SF1 TMEM14A TMEM230 TMEM33 TMX2 TPP2 TRIP12 TUBB TVP23B UBA1 UBAP2L UBQLN1 UBR4 USP28 USP32 USP34 VAPB VARS1 WAPL WASHC4 YWHAB YWHAZ ZC3H11A ZDHHC16 ZNF460	70 interacting genes: A2M APC APOB BAG3 BCAR1 CASP7 CPT1A DDX24 DNAJC1 DNAJC10 DNAJC3 DPH1 DPYSL5 EIF2AK3 ERBB2 ERCC6 ERN1 ERP29 F8 FCHSD2 GRB2 GRIA1 HLA-C HMGB1 HSPB1 HSPBP1 HTR3A IGHM KRT14 KRT18 KRT8 LCT LDLR LINC01554 MATK METTL21A MTNR1A MTNR1B NDRG1 OTUD3 PARK7 PAWR PCSK7 PRNP PSME3 PTPN11 PTPRF RPN1 SEC61A1 SEC63 SERPINB5 SH3BP4 SIL1 SIRPA SQSTM1 SREBF2 STMN1 SUMO2 SUMO4 TCERG1 TG TMEM132A TMEM62 TRA TSHR UBE3A UBQLN4 VHL VWF YWHAB
Entrez ID		4543	3309
HPRD ID		02812	00682
Ensembl ID		ENSG00000168412	ENSG00000044574
Uniprot IDs		P48039	P11021 V9HWB4
PDB IDs		6ME2 6ME3 6ME4 6ME5	3IUC 3LDL 3LDN 3LDO 3LDP 5E84 5E85 5E86 5EVZ 5EX5 5EXW 5EY4 5F0X 5F1X 5F2R 6ASY 6CZ1 6DFM 6DFO 6DO2 6DWS
Enriched GO Terms of Interacting Partners?
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