HSPA5 and RPN1

Data Source:
BioGRID (pull down)

		HSPA5	RPN1
Description		heat shock protein family A (Hsp70) member 5	ribophorin I
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Endoplasmic Reticulum-Golgi Intermediate Compartment Cytosol Plasma Membrane Focal Adhesion COP9 Signalosome Cell Surface Membrane Integral Component Of Endoplasmic Reticulum Membrane Midbody Protein-containing Complex Endoplasmic Reticulum Chaperone Complex Melanosome Intracellular Membrane-bounded Organelle Extracellular Exosome	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Cytosol Oligosaccharyltransferase Complex Membrane Integral Component Of Membrane Melanosome
	Molecular Function	Calcium Ion Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding Protein Domain Specific Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding Ribosome Binding Protein Folding Chaperone Cadherin Binding Unfolded Protein Binding Chaperone Binding Misfolded Protein Binding	RNA Binding Dolichyl-diphosphooligosaccharide-protein Glycotransferase Activity Protein Binding
	Biological Process	Luteolysis ER Overload Response Positive Regulation Of Neuron Projection Development Cerebellum Structural Organization Cerebellar Purkinje Cell Layer Development Substantia Nigra Development Neuron Differentiation Positive Regulation Of Cell Migration Ubiquitin-dependent ERAD Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Endoplasmic Reticulum Unfolded Protein Response Posttranslational Protein Targeting To Membrane, Translocation Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein Ubiquitination Cellular Response To Unfolded Protein Protein Folding In Endoplasmic Reticulum Maintenance Of Protein Localization In Endoplasmic Reticulum Cellular Response To Drug IRE1-mediated Unfolded Protein Response PERK-mediated Unfolded Protein Response ATF6-mediated Unfolded Protein Response Protein Refolding Cellular Response To Glucose Starvation Response To Cocaine Negative Regulation Of Apoptotic Process Chaperone Cofactor-dependent Protein Refolding Neuron Apoptotic Process Regulation Of Protein Folding In Endoplasmic Reticulum Cellular Response To Antibiotic Cellular Response To Calcium Ion Cellular Response To Manganese Ion Cellular Response To CAMP Cellular Response To Interleukin-4 Cellular Response To Gamma Radiation Stress Response To Metal Ion Toxin Transport Regulation Of ATF6-mediated Unfolded Protein Response Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of PERK-mediated Unfolded Protein Response Response To Methamphetamine Hydrochloride Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress	Cellular Protein Modification Process Protein N-linked Glycosylation Protein N-linked Glycosylation Via Asparagine
Pathways		Platelet degranulation Regulation of HSF1-mediated heat shock response ATF6 (ATF6-alpha) activates chaperones PERK regulates gene expression IRE1alpha activates chaperones ATF6 (ATF6-alpha) activates chaperone genes Antigen Presentation: Folding, assembly and peptide loading of class I MHC Antigen Presentation: Folding, assembly and peptide loading of class I MHC	SRP-dependent cotranslational protein targeting to membrane Asparagine N-linked glycosylation Maturation of spike protein
Drugs		Antihemophilic factor, human recombinant Acetylsalicylic acid Copper Lonoctocog alfa Moroctocog alfa
Diseases
GWAS		Refractive error ( 32231278)	Blood protein levels ( 30072576 29875488) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Eosinophil counts ( 29403010 27863252) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mild to moderate chronic kidney disease ( 31178898) Monocyte count ( 23314186 29403010 27863252) Monocyte percentage of white cells ( 32888494 27863252) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Neutrophil count ( 32888494) Platelet distribution width ( 32888494) Sum eosinophil basophil counts ( 27863252) White blood cell count ( 32888494 21738480) White blood cell count (basophil) ( 29403010)
Interacting Genes		70 interacting genes: A2M APC APOB BAG3 BCAR1 CASP7 CPT1A DDX24 DNAJC1 DNAJC10 DNAJC3 DPH1 DPYSL5 EIF2AK3 ERBB2 ERCC6 ERN1 ERP29 F8 FCHSD2 GRB2 GRIA1 HLA-C HMGB1 HSPB1 HSPBP1 HTR3A IGHM KRT14 KRT18 KRT8 LCT LDLR LINC01554 MATK METTL21A MTNR1A MTNR1B NDRG1 OTUD3 PARK7 PAWR PCSK7 PRNP PSME3 PTPN11 PTPRF RPN1 SEC61A1 SEC63 SERPINB5 SH3BP4 SIL1 SIRPA SQSTM1 SREBF2 STMN1 SUMO2 SUMO4 TCERG1 TG TMEM132A TMEM62 TRA TSHR UBE3A UBQLN4 VHL VWF YWHAB	17 interacting genes: ADRM1 CAMLG DPF1 DUX4 ERBB3 HSPA5 KRTAP1-3 RAD23A RBBP4 SGTA SIGIRR SMARCB1 UBC UBQLN1 UBQLN2 UBQLN4 WSB2
Entrez ID		3309	6184
HPRD ID		00682	01598
Ensembl ID		ENSG00000044574	ENSG00000163902
Uniprot IDs		P11021 V9HWB4	P04843
PDB IDs		3IUC 3LDL 3LDN 3LDO 3LDP 5E84 5E85 5E86 5EVZ 5EX5 5EXW 5EY4 5F0X 5F1X 5F2R 6ASY 6CZ1 6DFM 6DFO 6DO2 6DWS	6S7O 6S7T
Enriched GO Terms of Interacting Partners?
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