BTC and GMPPA

Data Source:
BioGRID (two hybrid, two hybrid)

		BTC	GMPPA
Description		betacellulin	GDP-mannose pyrophosphorylase A
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Membrane Clathrin-coated Vesicle Membrane	Cytoplasm Extracellular Exosome
	Molecular Function	Epidermal Growth Factor Receptor Binding Protein Binding Growth Factor Activity	Protein Binding Nucleotidyltransferase Activity
	Biological Process	MAPK Cascade Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of Urine Volume ERBB2 Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Cell Differentiation Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Cell Division Positive Regulation Of Protein Kinase B Signaling Membrane Organization Regulation Of Cell Motility	Biosynthetic Process
Pathways		Signaling by ERBB2 Signaling by ERBB4 SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling PI3K events in ERBB4 signaling SHC1 events in ERBB4 signaling Nuclear signaling by ERBB4 PIP3 activates AKT signaling Signaling by EGFR GRB2 events in EGFR signaling GAB1 signalosome SHC1 events in EGFR signaling EGFR downregulation GRB2 events in ERBB2 signaling PI3K events in ERBB2 signaling EGFR interacts with phospholipase C-gamma Constitutive Signaling by Aberrant PI3K in Cancer Inhibition of Signaling by Overexpressed EGFR RAF/MAP kinase cascade ERBB2 Regulates Cell Motility PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling ERBB2 Activates PTK6 Signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Downregulation of ERBB2 signaling Extra-nuclear estrogen signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling Signaling by ERBB2 KD Mutants Signaling by ERBB2 TMD/JMD mutants	Synthesis of GDP-mannose
Drugs
Diseases
GWAS		Breast size ( 27182965) Chronic obstructive pulmonary disease ( 30804561) Diverticular disease ( 30177863) Electroencephalogram traits ( 25387704) FEV1 ( 30804560) Lung function (FEV1/FVC) ( 30804560)
Interacting Genes		11 interacting genes: DNAJC5 EGFR ERBB2 ERBB4 GMPPA KPRP KRT31 KRTAP1-3 MMP9 SGTA SGTB	9 interacting genes: BTC CDR2 CRP DCUN1D1 GMPPB GPKOW LSM8 NCK1 ZNF688
Entrez ID		685	29926
HPRD ID		02643	13588
Ensembl ID		ENSG00000174808	ENSG00000144591
Uniprot IDs		A0A0S2Z3I5 A0A0S2Z437 P35070	A0A384MDS7 Q96IJ6
PDB IDs		1IOX 1IP0
Enriched GO Terms of Interacting Partners?
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