MSRA and HPCAL4

Data Source:
BioGRID (two hybrid)

		MSRA	HPCAL4
Description		methionine sulfoxide reductase A	hippocalcin like 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol Plasma Membrane Actin Cytoskeleton Extracellular Exosome
	Molecular Function	Protein Binding Peptide-methionine (S)-S-oxide Reductase Activity L-methionine-(S)-S-oxide Reductase Activity	Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Protein C-terminus Binding Protein Domain Specific Binding
	Biological Process	Cellular Protein Modification Process Methionine Metabolic Process Response To Oxidative Stress Protein Repair Cellular Response To Oxidative Stress	Signal Transduction Central Nervous System Development
Pathways		Protein repair
Drugs		1,4-Dithiothreitol
Diseases
GWAS		Adiposity ( 19557161) Adult body size ( 32376654) Age at first sexual intercourse ( 27089180) Alzheimer's disease ( 20452100) Asthma-chronic obstructive pulmonary disease overlap syndrome ( 30657218) Autoimmune thyroid disease ( 32581359) Barrett's esophagus ( 27527254) Barrett's esophagus or Esophageal adenocarcinoma ( 27527254) Bipolar disorder ( 31043756) Bipolar disorder and schizophrenia ( 22688191) Body mass index ( 30108283 31453325) Body mass index variance ( 31453325) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Bulimia nervosa ( 23568457) Chronotype ( 26835600) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cooked vegetable consumption ( 32066663) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Estimated glomerular filtration rate ( 31152163) Feeling worry ( 29500382) Fish- and plant-related diet ( 32066663) Fruit consumption ( 32066663) General factor of neuroticism ( 30867560) General risk tolerance (MTAG) ( 30643258) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) HDL cholesterol levels ( 32203549) Hypertension ( 19430479) Insomnia ( 32332799) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Irritable mood ( 29500382) Joint mobility (Beighton score) ( 27182965) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (diuretics) ( 31015401) Medication use (thyroid preparations) ( 31015401) Myopia (pathological) ( 23049088) Neurociticism ( 29500382) Nose size ( 27182965) Obesity (early onset extreme) ( 20421936) Oily fish consumption ( 32066663) Plasma kynurenine to tryptophan ratio in major depressive disorder ( 29317604) Pork consumption ( 32066663) Processed meat consumption ( 32066663) Pulse pressure ( 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Raw vegetable consumption ( 32066663) Refractive error ( 32231278) Remission after SSRI treatment in MDD or neuroticism ( 29559929) Response to chemotherapy in breast cancer hypertensive cases (cumulative dose) (bevacizumab) ( 25117820) Schizophrenia ( 28991256 21679298 30285260 26198764) Smoking initiation (ever regular vs never regular) ( 30679032) Systemic lupus erythematosus ( 28714469) Systolic blood pressure ( 30224653 30578418) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) TPE interval (resting) ( 32386560) Triglyceride levels ( 32203549) Type 2 diabetes ( 30297969) Waist circumference ( 30108283) Weight ( 30108283)	Bone mineral density (Ward's triangle area) ( 27397699)
Interacting Genes		6 interacting genes: CTNNA3 EFCAB11 FBXL3 HPCAL4 P4HA3 SELENBP1	16 interacting genes: ANKRD33 AQP4 CDSN CEACAM6 DTX2 F3 FAM131C LITAF MSRA SCMH1 SPRED1 TEX13B TRPM5 TSC22D3 TTC12 UBE3A
Entrez ID		4482	51440
HPRD ID		03152	17113
Ensembl ID		ENSG00000175806	ENSG00000116983
Uniprot IDs		Q9UJ68	B4DGW9 Q9UM19
PDB IDs
Enriched GO Terms of Interacting Partners?
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