HPCAL4 and F3

Data Source:
BioGRID (two hybrid)

		HPCAL4	F3
Description		hippocalcin like 4	coagulation factor III, tissue factor
Image		No pdb structure
GO Annotations	Cellular Component		Extracellular Space Plasma Membrane Cell Surface Integral Component Of Membrane Intrinsic Component Of External Side Of Plasma Membrane Collagen-containing Extracellular Matrix Serine-type Peptidase Complex
	Molecular Function	Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Protein C-terminus Binding Protein Domain Specific Binding	Protease Binding Serine-type Endopeptidase Activity Cytokine Receptor Activity Protein Binding Phospholipid Binding
	Biological Process	Signal Transduction Central Nervous System Development	Positive Regulation Of Endothelial Cell Proliferation Activation Of Plasma Proteins Involved In Acute Inflammatory Response Activation Of Blood Coagulation Via Clotting Cascade Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Blood Coagulation Blood Coagulation, Extrinsic Pathway Positive Regulation Of Gene Expression Positive Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Protein Processing Cytokine-mediated Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Interleukin-8 Production Positive Regulation Of Angiogenesis Positive Regulation Of Positive Chemotaxis Positive Regulation Of Protein Kinase B Signaling
Pathways			Extrinsic Pathway of Fibrin Clot Formation NGF-stimulated transcription
Drugs			Coagulation factor VIIa Recombinant Human rNAPc2 2-(4-HYDROXY-5-PHENYL-1H-PYRAZOL-3-YL)-1H-BENZOIMIDAZOLE-5-CARBOXAMIDINE [2'-HYDROXY-3'-(1H-PYRROLO[3,2-C]PYRIDIN-2-YL)-BIPHENYL-3-YLMETHYL]-UREA [5-(5-Amino-1H-pyrrolo[3,2-b]pyridin-2-yl)-6-hydroxy-3'-nitro-3-biphenylyl]acetic acid Coagulation factor VII human
Diseases
GWAS		Bone mineral density (Ward's triangle area) ( 27397699)	Blood protein levels in cardiovascular risk ( 28369058) D-dimer levels ( 21502573) End-stage coagulation ( 23381943) Smoking status (heavy vs never) ( 26423011) Type 2 diabetes ( 22238593)
Interacting Genes		16 interacting genes: ANKRD33 AQP4 CDSN CEACAM6 DTX2 F3 FAM131C LITAF MSRA SCMH1 SPRED1 TEX13B TRPM5 TSC22D3 TTC12 UBE3A	8 interacting genes: F10 F7 FANCB FLNA HPCAL4 MDM2 PLG PTPA
Entrez ID		51440	2152
HPRD ID		17113	00603
Ensembl ID		ENSG00000116983	ENSG00000117525
Uniprot IDs		B4DGW9 Q9UM19	P13726
PDB IDs			1AHW 1BOY 1DAN 1FAK 1J9C 1JPS 1NL8 1O5D 1TFH 1UJ3 1W0Y 1W2K 1WQV 1WSS 1WTG 1WUN 1WV7 1Z6J 2A2Q 2AEI 2AER 2B7D 2B8O 2C4F 2CEF 2CEH 2CEZ 2CFJ 2EC9 2F9B 2FIR 2FLB 2FLR 2HFT 2PUQ 2ZP0 2ZWL 2ZZU 3ELA 3TH2 3TH3 3TH4 4IBL 4M7L 4YLQ 4Z6A 4ZMA 5W06 6R2W
Enriched GO Terms of Interacting Partners?
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