KRTAP5-7 and DOCK2

Data Source:
BioGRID (two hybrid)

		KRTAP5-7	DOCK2
Description		keratin associated protein 5-7	dedicator of cytokinesis 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Keratin Filament	Extracellular Region Cytosol Cytoskeleton Membrane Specific Granule Lumen Extracellular Exosome
	Molecular Function	Protein Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding T Cell Receptor Binding
	Biological Process	Keratinization	Membrane Raft Polarization Establishment Of T Cell Polarity Immunological Synapse Formation Myeloid Dendritic Cell Activation Involved In Immune Response Chemotaxis Small GTPase Mediated Signal Transduction Actin Cytoskeleton Organization Neutrophil Degranulation Positive Regulation Of GTPase Activity Macropinocytosis Positive Thymic T Cell Selection Negative Thymic T Cell Selection Alpha-beta T Cell Proliferation Regulation Of Defense Response To Virus By Virus Positive Regulation Of Phagocytosis
Pathways		Keratinization	Nef and signal transduction Neutrophil degranulation Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS			Acne (severe) ( 24927181) Body mass index and waist-hip ratio (pleiotropy) ( 29868124) Placental abruption ( 29884306) Pneumococcal bacteremia ( 27236921) Prostate cancer ( 29892016) Protein quantitative trait loci ( 18464913)
Interacting Genes		61 interacting genes: ADAMTSL3 ADAMTSL4 CARD9 CD300LG COL8A1 CRCT1 CREB5 CRY2 CYSRT1 DMRT3 DOCK2 FAM161A GUCD1 HHEX HOXB9 IGFBP6 IGSF8 IL2RG ITGB5 KPRP KRTAP10-1 KRTAP10-10 KRTAP4-2 KRTAP4-4 KRTAP5-11 KRTAP5-2 KRTAP5-6 KRTAP9-2 LCE1A LCE1B LCE1E LCE2B LCE2C LCE2D LCE3A LCE3B LCE3D LCE3E LCE4A MACO1 MAPKBP1 MRGBP MXI1 MYOM1 PHLDA1 PTPMT1 RAMP3 SAMD11 SCARF1 SDC3 SHFL SLC39A7 SPATA3 TRIM42 UXT WNT11 ZNF330 ZNF440 ZNF479 ZNF587 ZNF613	48 interacting genes: CALCOCO2 CARD10 CCNDBP1 CD247 CRKL CYSRT1 ELMO1 GOLGA6L9 HNRNPK HOXA1 KHDRBS1 KHDRBS2 KHDRBS3 KRT31 KRT34 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP17-1 KRTAP3-1 KRTAP3-3 KRTAP4-2 KRTAP5-7 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 MDFI MTDH MTUS2 NBPF19 NOTCH2NLA PAK2 PCSK5 PLEKHF2 PLSCR1 RAC1 RAC2 TENM4 TGM1 TRIM23 VAV1
Entrez ID		440050	1794
HPRD ID		17251	09121
Ensembl ID		ENSG00000244411	ENSG00000134516
Uniprot IDs		Q6L8G8	Q5XG91 Q92608
PDB IDs			2RQR 2YIN 3A98 3B13 6TGB 6TGC
Enriched GO Terms of Interacting Partners?
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