DOCK2 and TENM4

Data Source:
BioGRID (two hybrid)

		DOCK2	TENM4
Description		dedicator of cytokinesis 2	teneurin transmembrane protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytosol Cytoskeleton Membrane Specific Granule Lumen Extracellular Exosome	Nucleus Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Neuron Projection
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding T Cell Receptor Binding	Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Cell Adhesion Molecule Binding
	Biological Process	Membrane Raft Polarization Establishment Of T Cell Polarity Immunological Synapse Formation Myeloid Dendritic Cell Activation Involved In Immune Response Chemotaxis Small GTPase Mediated Signal Transduction Actin Cytoskeleton Organization Neutrophil Degranulation Positive Regulation Of GTPase Activity Macropinocytosis Positive Thymic T Cell Selection Negative Thymic T Cell Selection Alpha-beta T Cell Proliferation Regulation Of Defense Response To Virus By Virus Positive Regulation Of Phagocytosis	Gastrulation With Mouth Forming Second Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Signal Transduction Regulation Of Myelination Positive Regulation Of Myelination Central Nervous System Myelin Formation Neuron Development Positive Regulation Of Oligodendrocyte Differentiation Cardiac Muscle Cell Proliferation Cardiac Cell Fate Specification Positive Regulation Of Gastrulation
Pathways		Nef and signal transduction Neutrophil degranulation Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Acne (severe) ( 24927181) Body mass index and waist-hip ratio (pleiotropy) ( 29868124) Placental abruption ( 29884306) Pneumococcal bacteremia ( 27236921) Prostate cancer ( 29892016) Protein quantitative trait loci ( 18464913)	Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Hair greying ( 26926045) Lactate dehydrogenase levels ( 29403010) Lung cancer in never smokers ( 28604730) Night sleep phenotypes ( 27126917) Right lateral prefrontal cortical growth ( 29682794) Tourette syndrome ( 30818990)
Interacting Genes		48 interacting genes: CALCOCO2 CARD10 CCNDBP1 CD247 CRKL CYSRT1 ELMO1 GOLGA6L9 HNRNPK HOXA1 KHDRBS1 KHDRBS2 KHDRBS3 KRT31 KRT34 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP17-1 KRTAP3-1 KRTAP3-3 KRTAP4-2 KRTAP5-7 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 MDFI MTDH MTUS2 NBPF19 NOTCH2NLA PAK2 PCSK5 PLEKHF2 PLSCR1 RAC1 RAC2 TENM4 TGM1 TRIM23 VAV1	8 interacting genes: DOCK2 HOXB9 LCE3D LGALS4 PLSCR4 SHFL ZNF587 ZNF696
Entrez ID		1794	26011
HPRD ID		09121	19400
Ensembl ID		ENSG00000134516	ENSG00000149256
Uniprot IDs		Q5XG91 Q92608	Q6N022
PDB IDs		2RQR 2YIN 3A98 3B13 6TGB 6TGC
Enriched GO Terms of Interacting Partners?
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