MRE11 and DCLRE1C

Data Source:
HPRD (in vivo, in vitro)

		MRE11	DCLRE1C
Description		MRE11 homolog, double strand break repair nuclease	DNA cross-link repair 1C
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Cytoplasm Cytosol PML Body Mre11 Complex Site Of Double-strand Break	Nucleoplasm Golgi Apparatus Nonhomologous End Joining Complex
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity DNA Binding DNA Helicase Activity Double-stranded DNA Binding Nuclease Activity Endodeoxyribonuclease Activity Protein Binding Protein C-terminus Binding 3'-5' Exonuclease Activity 5'-3' Exonuclease Activity Manganese Ion Binding Identical Protein Binding Cadherin Binding	Single-stranded DNA Endodeoxyribonuclease Activity Damaged DNA Binding Endonuclease Activity Protein Binding 5'-3' Exonuclease Activity 5'-3' Exodeoxyribonuclease Activity
	Biological Process	Regulation Of Mitotic Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing DNA Replication DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Cellular Response To DNA Damage Stimulus Telomere Maintenance Via Telomerase Sister Chromatid Cohesion Mitotic G2 DNA Damage Checkpoint Homologous Chromosome Pairing At Meiosis Reciprocal Meiotic Recombination Cell Population Proliferation Viral Process Intra-S DNA Damage Checkpoint Telomeric 3' Overhang Formation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Telomere Maintenance Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding Positive Regulation Of Kinase Activity Meiotic DNA Double-strand Break Formation Negative Regulation Of Apoptotic Process Mitochondrial Double-strand Break Repair Via Homologous Recombination DNA Strand Resection Involved In Replication Fork Processing Regulation Of Signal Transduction By P53 Class Mediator	Adaptive Immune Response Double-strand Break Repair Via Nonhomologous End Joining Response To Ionizing Radiation B Cell Differentiation Protection From Non-homologous End Joining At Telomere V(D)J Recombination Interstrand Cross-link Repair Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Cytosolic sensors of pathogen-associated DNA DNA Damage/Telomere Stress Induced Senescence IRF3-mediated induction of type I IFN HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Meiotic recombination	Nonhomologous End-Joining (NHEJ)
Drugs
Diseases		DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome Ataxia with ocular apraxia (AOA), including: Ataxia telangiectasia (AT); Ataxia telangiectasia like disorder (ATLD); Ataxia oculomotor apraxia type 1 (AOA1); Ataxia oculomotor apraxia type 2 (AOA2)	T-B-Severe combined immunodeficiencies (SCIDs), including the following four diseases: Adenosine deaminase (ADA) deficiency; Recombinase activating gene (RAG) deficiencies; Artemis deficiency; Reticular dysgenesis
GWAS			Lymphocyte counts ( 32888494) Monocyte count ( 32888494) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)
Interacting Genes		20 interacting genes: ATM ATR CCNE1 CDK2 DCLRE1C DYNLL1 EP300 FANCD2 H2AX LIG1 MAPK8IP2 NBN NEK1 PRKDC RAD50 RECQL5 SPOP SUMO1 SUMO2 XRCC6	10 interacting genes: ATM ATR BRCA1 CDKN1B DDB2 MRE11 NBN PRKDC RAD50 TP53BP1
Entrez ID		4361	64421
HPRD ID		02889	05817
Ensembl ID		ENSG00000020922	ENSG00000152457
Uniprot IDs		A0A024R395 F8W7U8 P49959 Q05D78	B3KMX5 Q96SD1
PDB IDs		3T1I	3W1B 3W1G 4HTP 6TT5 6WNL 6WO0 7AF1 7AFS 7AFU 7AGI
Enriched GO Terms of Interacting Partners?
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