MRE11 and FANCD2

Data Source:
HPRD (in vivo)

		MRE11	FANCD2
Description		MRE11 homolog, double strand break repair nuclease	FA complementation group D2
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Cytoplasm Cytosol PML Body Mre11 Complex Site Of Double-strand Break	Condensed Chromosome Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Body
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity DNA Binding DNA Helicase Activity Double-stranded DNA Binding Nuclease Activity Endodeoxyribonuclease Activity Protein Binding Protein C-terminus Binding 3'-5' Exonuclease Activity 5'-3' Exonuclease Activity Manganese Ion Binding Identical Protein Binding Cadherin Binding	Protein Binding DNA Polymerase Binding
	Biological Process	Regulation Of Mitotic Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing DNA Replication DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Cellular Response To DNA Damage Stimulus Telomere Maintenance Via Telomerase Sister Chromatid Cohesion Mitotic G2 DNA Damage Checkpoint Homologous Chromosome Pairing At Meiosis Reciprocal Meiotic Recombination Cell Population Proliferation Viral Process Intra-S DNA Damage Checkpoint Telomeric 3' Overhang Formation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Telomere Maintenance Positive Regulation Of Type I Interferon Production DNA Duplex Unwinding Positive Regulation Of Kinase Activity Meiotic DNA Double-strand Break Formation Negative Regulation Of Apoptotic Process Mitochondrial Double-strand Break Repair Via Homologous Recombination DNA Strand Resection Involved In Replication Fork Processing Regulation Of Signal Transduction By P53 Class Mediator	Homologous Chromosome Pairing At Meiosis Gamete Generation Response To Gamma Radiation Intra-S DNA Damage Checkpoint Cellular Response To Oxidative Stress Interstrand Cross-link Repair Regulation Of Regulatory T Cell Differentiation Brain Morphogenesis Regulation Of Inflammatory Response Regulation Of DNA-binding Transcription Factor Activity Neuronal Stem Cell Population Maintenance Double-strand Break Repair Involved In Meiotic Recombination Regulation Of CD40 Signaling Pathway
Pathways		Cytosolic sensors of pathogen-associated DNA DNA Damage/Telomere Stress Induced Senescence IRF3-mediated induction of type I IFN HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Meiotic recombination	Fanconi Anemia Pathway TP53 Regulates Transcription of DNA Repair Genes
Drugs
Diseases		DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome Ataxia with ocular apraxia (AOA), including: Ataxia telangiectasia (AT); Ataxia telangiectasia like disorder (ATLD); Ataxia oculomotor apraxia type 1 (AOA1); Ataxia oculomotor apraxia type 2 (AOA2)	Fanconi anemia
GWAS			Alzheimer's disease ( 24755620) Waist-to-hip ratio adjusted for BMI ( 28552196)
Interacting Genes		20 interacting genes: ATM ATR CCNE1 CDK2 DCLRE1C DYNLL1 EP300 FANCD2 H2AX LIG1 MAPK8IP2 NBN NEK1 PRKDC RAD50 RECQL5 SPOP SUMO1 SUMO2 XRCC6	28 interacting genes: ATM ATR BLM BRCA1 BRCA2 BRIP1 FANCC FANCE FANCI FANCL H2AC4 H2BC3 H3C1 H4C1 MEN1 MRE11 NBN PCNA RAD51 TERF1 TNFRSF1A TNFRSF1B TNKS UBB UBE2T UHRF1 UHRF2 USP1
Entrez ID		4361	2177
HPRD ID		02889	01968
Ensembl ID		ENSG00000020922	ENSG00000144554
Uniprot IDs		A0A024R395 F8W7U8 P49959 Q05D78	Q9BXW9
PDB IDs		3T1I	6VAA 6VAD 6VAE 6VAF
Enriched GO Terms of Interacting Partners?
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